Evidence map›Paper›PMID 36140298›Full record

ArticleBiomedicines2022

Calcium Overload or Underload? The Effects of Doxorubicin on the Calcium Dynamics in Guinea Pig Hearts.

Jingjing Wu, Linlin Gao, Hong Fan, Deming Liu, Mengxue Lin, Ming Zhu, Tian Deng, Yuanlong Song

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jingjing WuDepartment of Cardiology, Huazhong University of Science and Technology, Wuhan 430022, China.
Linlin GaoDepartment of Physiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hong FanDepartment of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Deming LiuNational Engineering Laboratory for Next-Generation Internet Access System (NEL-NGIA), Huazhong University of Science and Technology, Wuhan 430022, China.
Mengxue LinSchool of Electronic Information and Communications, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0000-0003-1288-5101
Ming ZhuSchool of Electronic Information and Communications, Huazhong University of Science and Technology, Wuhan 430074, China.
Tian DengSchool of Electronic Information and Communications, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0000-0003-4265-788X
Yuanlong SongDepartment of Physiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Huazhong University of Science and Technology · CNUnion Hospital · CN

Funding

the National Natural Science Foundation of China 31771190
6 · The paper itself

Abstract

The severe doxorubicin (DOXO) side effect of cardiomyopathy limits it clinical application as an effective anticancer drug. Although Ca

Indexed as

doxorubicin toxicityintracellular Ca2+optical mapping

Identifiers

PMID36140298
PMCPMC9496179
OpenAlexW4294718965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.