Evidence map›Paper›PMID 36140256›Full record

ArticleBiomedicines2022

The Effects of H

Sergei Onikienko, Maxim Vinokurov, Marina Yurinskaya, Alexander Zemlyanoi, Sergei Abkin, Elvira Shaykhutdinova, Victor Palikov, Alexander Ivanov, Olga Smirnova, Irina Fedyakina and 4 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Sergei OnikienkoSaint-Petersburg Scientific Center, RAS (Russian Academy of Sciences), 199034 St. Petersburgh, Russia.
Maxim VinokurovInstitute of Cell Biophysics, RAS (Russian Academy of Sciences), 142290 Pushchino, Russia.
Marina YurinskayaInstitute of Cell Biophysics, RAS (Russian Academy of Sciences), 142290 Pushchino, Russia.
Alexander ZemlyanoiSaint-Petersburg Scientific Center, RAS (Russian Academy of Sciences), 199034 St. Petersburgh, Russia.
Sergei AbkinSaint-Petersburg Scientific Center, RAS (Russian Academy of Sciences), 199034 St. Petersburgh, Russia.
Elvira ShaykhutdinovaInstitute of Bioorganic Chemistry, RAS (Russian Academy of Sciences), 142290 Pushchino, Russia.
Victor PalikovInstitute of Bioorganic Chemistry, RAS (Russian Academy of Sciences), 142290 Pushchino, Russia.ORCID 0000-0003-2989-4477
Alexander IvanovEngelhardt Institute of Molecular Biology, RAS (Russian Academy of Sciences), 119991 Moscow, Russia.ORCID 0000-0002-5659-9679
Olga SmirnovaEngelhardt Institute of Molecular Biology, RAS (Russian Academy of Sciences), 119991 Moscow, Russia.
Irina FedyakinaEngelhardt Institute of Molecular Biology, RAS (Russian Academy of Sciences), 119991 Moscow, Russia.
Natalia BychkovaThe Nikiforov Russian Centre of Emergency and Radiation Medicine, 194044, St. Petersburg, Russia.
Olga ZatsepinaEngelhardt Institute of Molecular Biology, RAS (Russian Academy of Sciences), 119991 Moscow, Russia.
David GarbuzEngelhardt Institute of Molecular Biology, RAS (Russian Academy of Sciences), 119991 Moscow, Russia.
Michael Evgen'evEngelhardt Institute of Molecular Biology, RAS (Russian Academy of Sciences), 119991 Moscow, Russia.
Engelhardt Institute of Molecular Biology · RURussian Academy of Sciences · RUInstitute of Bioorganic Chemistry · RUInstitute of Cell Biophysics · RUNikiforov Russian Center of Emergency and Radiation Medicine · RU

Funding

Russian Science Foundation 17-74-30030; 19-14-00167
6 · The paper itself

Abstract

The ongoing epidemic caused by SARS-CoV-2 infection led to the search for fundamentally new ways and means to combat inflammation and other pathologies caused by this virus. Using a cellular model of lipopolysaccharide (LPS)-induced sepsis (human promonocytes), we showed that both a hydrogen sulfide donor (sodium thiosulfate, STS) and a recombinant Heat shock protein 70 (rHsp70) effectively block all major inflammatory mediators when administrated before and after LPS challenge. The protective anti-inflammatory effect of rHsp70 and H

Indexed as

COVID-19inflammationLPS-challengepneumoniarHsp70sodium thiosulfate

Identifiers

PMID36140256
PMCPMC9496158
OpenAlexW4294132078

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.