Evidence map›Paper›PMID 36140245›Full record

ArticleBiomedicines2022

Eltanexor Effectively Reduces Viability of Glioblastoma and Glioblastoma Stem-Like Cells at Nano-Molar Concentrations and Sensitizes to Radiotherapy and Temozolomide.

Katharina Otte, Kai Zhao, Madita Braun, Andreas Neubauer, Hartmann Raifer, Frederik Helmprobst, Felipe Ovalle Barrera, Christopher Nimsky, Jörg W Bartsch, Tillmann Rusch

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Katharina OtteDepartment of Neurosurgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany.
Kai ZhaoDepartment of Neurosurgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany.
Madita BraunDepartment of Neurosurgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany.
Andreas NeubauerDepartment of Hematology, Oncology & Immunology, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany.
Hartmann RaiferFACS Core Facility, Philipps University Marburg, Hans-Meerwein-Strasse 3, 35043 Marburg, Germany.
Frederik HelmprobstDepartment of Neuropathology, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany.
Felipe Ovalle BarreraDepartment of Neuropathology, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany.
Christopher NimskyDepartment of Neurosurgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany.ORCID 0000-0002-8216-9410
Jörg W BartschDepartment of Neurosurgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany.ORCID 0000-0002-2773-3357
Tillmann RuschDepartment of Hematology, Oncology & Immunology, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany.
Philipps University of Marburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current standard adjuvant therapy of glioblastoma multiforme (GBM) using temozolomide (TMZ) frequently fails due to therapy resistance. Thus, novel therapeutic approaches are highly demanded. We tested the therapeutic efficacy of the second-generation XPO1 inhibitor Eltanexor using assays for cell viability and apoptosis in GBM cell lines and GBM stem-like cells. For most GBM-derived cells, IC

Indexed as

EltanexorGBMradiosensitivitySINEtemozolomideXPO1

Identifiers

PMID36140245
PMCPMC9496210
OpenAlexW4294343870

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.