ReviewBiomedicines2022
Enhancement of Nitric Oxide Bioavailability by Modulation of Cutaneous Nitric Oxide Stores.
Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Assessment of Nitric Oxide Release In Vitro via Low-Level Daylight-Equivalent Blue or Red Light Irradiation.Antioxidants (Basel, Switzerland) · 2026Article
- Molecular signatures of hypertension in polycystic ovary syndrome: Endothelin-1 and CYP11A1 as biomarkers of vascular and metabolic dysfunction.Molecular biology reports · 2026Article
- Nitric oxide: a gas transmitter in healthy and diseased skin.Medical gas research · 2025Review
- Thermal-denatured PDRN exhibits increased in vitro pharmacological activities: A functional role of single-stranded DNA random coils.Experimental and therapeutic medicine · 2025Article
- Nitrate as Warden of Nitric Oxide Homeostasis in Mammals.Nutrients · 2025Review
- Pediatric Burn Treatment with Non-Thermal Atmospheric Plasma and EpifastEuropean burn journal · 2025Article
- Dual-layer microneedles with NO/OBioactive materials · 2025Article
- Harnessing Gasotransmitters to Combat Age-Related Oxidative Stress in Smooth Muscle and Endothelial Cells.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing.Journal of nanobiotechnology · 2025Review
- Acoustic therapy for allergic rhinitis and chronic rhinosinusitis: modulating microbiome, immunity and well-being.Frontiers in allergy · 2025Review
- The pathogenesis and therapeutic strategies of heat stroke-induced endothelial injury.Frontiers in cell and developmental biology · 2025Review
- Article
- Relationship between Lipoprotein Lipase Derived from Subcutaneous Adipose Tissue and Cardio-Ankle Vascular Index in Japanese Patients with Severe Obesity.Obesity facts · 2024Article
- Article
- Gas Flow-Dependent Modification of Plasma Chemistry in μAPP Jet-Generated Cold Atmospheric Plasma and Its Impact on Human Skin Fibroblasts.Biomedicines · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The generation of nitric oxide (NO) in the skin plays a critical role in wound healing and the response to several stimuli, such as UV exposure, heat, infection, and inflammation. Furthermore, in the human body, NO is involved in vascular homeostasis and the regulation of blood pressure. Physiologically, a family of enzymes termed nitric oxide synthases (NOS) generates NO. In addition, there are many methods of non-enzymatic/NOS-independent NO generation, e.g., the reduction of NO derivates (NODs) such as nitrite, nitrate, and nitrosylated proteins under certain conditions. The skin is the largest and heaviest human organ and contains a comparatively high concentration of these NODs; therefore, it represents a promising target for many therapeutic strategies for NO-dependent pathological conditions. In this review, we give an overview of how the cutaneous NOD stores can be targeted and modulated, leading to a further accumulation of NO-related compounds and/or the local and systemic release of bioactive NO, and eventually, NO-related physiological effects with a potential therapeutical use for diseases such as hypertension, disturbed microcirculation, impaired wound healing, and skin infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.