Evidence map›Paper›PMID 36140205›Full record

ArticleBiomedicines2022

Effect of D1- and D2-like Dopamine Receptor Antagonists on the Rewarding and Anxiolytic Effects of Neurotensin in the Ventral Pallidum.

Tamás Ollmann, László Lénárd, László Péczely, Beáta Berta, Erika Kertes, Olga Zagorácz, Edina Hormay, Kristóf László, Ádám Szabó, Rita Gálosi and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Tamás OllmannInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, Hungary.
László LénárdInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, Hungary.
László PéczelyInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, Hungary.
Beáta BertaInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, Hungary.
Erika KertesInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, Hungary.
Olga ZagoráczInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, Hungary.
Edina HormayInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, Hungary.
Kristóf LászlóInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, Hungary.
Ádám SzabóInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, Hungary.
Rita GálosiInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, Hungary.
Zoltán KarádiInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, Hungary.
Veronika KállaiInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, Hungary.
University of Pecs · HU

Funding

EFOP-3.6.1-16-2016-00004 EFOP-3.6.1-16-2016-00004New National Excellence Program of the Ministry for Innovation and Technology ÚNKP-21-5-PTE-1333, ÚNKP-16-3-IIIUniversity of Pécs, Medical School PTE ÁOK PD 2017-05, PTE ÁOK PD-2018-05, PTE ÁOK KA-2020-06
6 · The paper itself

Abstract

backgroundNeurotensin (NT) acts as a neurotransmitter and neuromodulator in the central nervous system. It was shown previously that NT in the ventral pallidum (VP) has rewarding and anxiolytic effects. NT exerts its effect in interaction with dopamine (DA) receptors in numerous brain areas; however, this has not yet been investigated in the VP. The aim of this study was to examine whether the inhibition of D1-like and D2-like DA receptors of the VP can modify the above mentioned effects of NT.

methodsMicroinjection cannulas were implanted by means of stereotaxic operations into the VP of male Wistar rats. The rewarding effect of NT was examined by means of a conditioned place preference test. Anxiety was investigated with an elevated plus maze test. To investigate the possible interaction, D1-like DA receptor antagonist SCH23390 or D2-like DA receptor antagonist sulpiride were microinjected prior to NT. All of the drugs were also injected independently to analyze their effects alone.

resultsIn the present experiments, both the rewarding and anxiolytic effects of NT in the VP were prevented by both D1-like and D2-like DA receptor antagonists. Administered on their own, the antagonists did not influence reward and anxiety.

conclusionOur present results show that the activity of the D1-like and D2-like DA receptors of the VP is a necessary requirement for both the rewarding and anxiolytic effects of NT.

Indexed as

anxietyconditioned place preferenceD1- and D2-like dopamine receptorselevated plus maze testneurotensinrewardventral pallidum

Identifiers

PMID36140205
PMCPMC9495457
OpenAlexW4293414581

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.