Evidence map›Paper›PMID 36140173›Full record

ArticleBiomedicines2022

Membranolytic Mechanism of Amphiphilic Antimicrobial β-Stranded [KL]

Fabian Schweigardt, Erik Strandberg, Parvesh Wadhwani, Johannes Reichert, Jochen Bürck, Haroldo L P Cravo, Luisa Burger, Anne S Ulrich

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Fabian SchweigardtKarlsruhe Institute of Technology (KIT), Institute of Organic Chemistry, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany.
Erik StrandbergKIT, Institute of Biological Interfaces (IBG-2), P.O. Box 3640, 76021 Karlsruhe, Germany.ORCID 0000-0002-2401-7478
Parvesh WadhwaniKIT, Institute of Biological Interfaces (IBG-2), P.O. Box 3640, 76021 Karlsruhe, Germany.ORCID 0000-0002-7290-5154
Johannes ReichertKIT, Institute of Biological Interfaces (IBG-2), P.O. Box 3640, 76021 Karlsruhe, Germany.
Jochen BürckKIT, Institute of Biological Interfaces (IBG-2), P.O. Box 3640, 76021 Karlsruhe, Germany.ORCID 0000-0002-2256-9498
Haroldo L P CravoLaboratório de Biofísica Molecular, Universidade de São Paulo, Ribeirão Preto 14040-901, SP, Brazil.
Luisa BurgerKIT, Institute of Biological Interfaces (IBG-2), P.O. Box 3640, 76021 Karlsruhe, Germany.
Anne S UlrichKarlsruhe Institute of Technology (KIT), Institute of Organic Chemistry, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany.ORCID 0000-0001-5571-9483
Karlsruhe Institute of Technology · DEUniversidade de São Paulo · BR

Funding

Deutsche Forschungsgemeinschaft INST 121384/58-1 FUGGDeutsche Forschungsgemeinschaft UL127/7-1Helmholtz Association of German Research Centres Program BIF-TM
6 · The paper itself

Abstract

Amphipathic peptides can act as antibiotics due to membrane permeabilization. KL peptides with the repetitive sequence [Lys-Leu]

Indexed as

antimicrobial activitycationic antimicrobial peptideshemolysislength dependent activitysolid-state 31P-, 15N- and 19F-NMRstructure and orientation of peptides in membranesvesicle leakageβ-sheetsβ-stranded peptides

Identifiers

PMID36140173
PMCPMC9495826
OpenAlexW4293009033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.