ArticleBiomedicines2022
Analysis of Human and Microbial Salivary Proteomes in Children Offers Insights on the Molecular Pathogenesis of Molar-Incisor Hypomineralization.
Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Electrochemical Biosensing Strategies for Oral Health: From Engineered Interfaces to Advanced Transistor Architectures.Advanced healthcare materials · 2026Review
- Comparative label-free quantitative proteomics of hypomineralised second primary molars (HSPM) and molar incisor hypomineralisation (MIH) reveals divergent enamel protein signatures underpinning distinct pathogenic mechanisms.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- The Oral-Gut-Brain Axis in Pediatric Populations: The Implications of Oral Dysbiosis for Systemic Inflammation and Neuroinflammation.Nutrients · 2026Review
- Clinical Evaluation of Association of Salivary and Plaque pH with Caries Severity in Children with Molar-incisor-hypomineralization in Haryana: A Cross-sectional Study.International journal of clinical pediatric dentistry · 2026Article
- Stimulated Salivary Flow Rate, Salivary pH, Viscosity, and Salivary Buffer Capacity and Their Relationship With Molar Incisor Hypomineralization in Mexican Schoolchildren.BioMed research international · 2026Article
- Evaluation of AQP5 in Hypomineralized Teeth in Comparison to Normal Teeth: A Cross-sectional Study.International journal of clinical pediatric dentistry · 2025Article
- Easy Proteomics Sample Preparation: Technical Repeatability and Workflow Optimization Across 8 Biological Matrices in a New Core Facility Setting.Proteomics · 2025Article
- Metagenomic Analysis of the Buccal Microbiome by Nanopore Sequencing Reveals Structural Differences in the Microbiome of a Patient with Molar Incisor Hypomineralization (MIH) Compared to a Healthy Child-Case Study.International journal of molecular sciences · 2024Article
- Relationship between cariogenic bacteria and molar incisor hypomineralization in Brazilian schoolchildren.Translational pediatrics · 2023Article
- Qualitative and Quantitative Mass Spectrometry in Salivary Metabolomics and Proteomics.Metabolites · 2023Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Molar incisor hypomineralization is a complex developmental enamel defect that affects the permanent dentition of children with significant functional and aesthetic implications. Saliva is an ideal diagnostic tool and ensures patients' compliance by diminishing the discomfort especially in pediatric population. Lately, salivary proteome analysis has progressively evolved in various biomedical disciplines. As changes in saliva composition are associated with oral diseases, it is reasonable to assume that the saliva proteome of MIH-affected children might be altered compared to healthy children. This study analyzed the human and microbial salivary proteome in children with MIH in order to identify salivary markers indicative of the pathology. The conducted proteomic analysis generated a comprehensive dataset comprising a total of 1515 high confidence identifications and revealed a clear discrimination between the two groups. Statistical comparison identified 142 differentially expressed proteins, while the pathway analysis indicated deregulation of inflammation, immune response mechanisms, and defense response to bacteria in MIH patients. Bacterial proteome analysis showed a lower diversity for the microbial species, which highlights the dysbiotic environment established in the MIH pathology.
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Registered trials
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