Evidence map›Paper›PMID 36140097›Full record

ArticleBiosensors2022

Micro-Volume Blood Separation Membrane for In-Situ Biosensing.

Qin Zhu, Huimin Wu, Zhen Ma, Yuqiao Liu, Junmin Li, Ling Zhu, Xinran Zhang, Chengcheng Wang, Dajing Chen, Danhua Zhu

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Qin ZhuState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 311100, China.
Huimin WuMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
Zhen MaSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Yuqiao LiuSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Junmin LiSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Ling ZhuSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Xinran ZhangSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Chengcheng WangSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Dajing ChenSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Danhua ZhuState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 311100, China.
Hangzhou Normal University · CNFirst Affiliated Hospital Zhejiang University · CNZhejiang University · CN

Funding

National Natural Science Foundation of China 61801160opening foundation of the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases SKLID2021KF01
6 · The paper itself

Abstract

In this paper, we report a point-of-care (POCT) testing strip based on a porous membrane structure for whole blood separation and colorimetric analysis without external supporting equipment. Conventional blood tests rely on large instruments for blood pretreatment and separation to improve measurement accuracy. Cellulose acetate (CA) membranes with different pore diameters and structures were prepared via a non-solvent method for the separation of whole blood. Among them, CA@PEG-2000 membranes with nano-pores on the surface and micro-pores in the interior facilitated the capture of blood cells on the surface, as well as the free diffusion of plasma through the porous interior structure. The fluid flow of blood in the asymmetric porous structure can be theoretically estimated using the Lucas-Washburn equation. Compared with the conventional paper strips and other porous membranes, the CA@PEG-2000 membrane with an immobilized sensing layer exhibited efficient blood separation, a short response time (less than 2 min), an ultralow dosage volume (5 μL), and high sensitivity. The fabricated blood separation membranes can be further used for the detection of various biomarkers in whole blood, providing additional options for rapid quantitative POCT tests.

Indexed as

ColorimetryPlasmaBiomarkersPoint-of-Care TestingPorosityBiomarkersblood separationcolorimetric assayporous membranes

Identifiers

PMID36140097
PMCPMC9496035
OpenAlexW4294989836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.