Evidence map›Paper›PMID 36139997›Full record

ArticleAntibiotics (Basel, Switzerland)2022

Silver Nanoparticle-Based Combinations with Antimicrobial Agents against Antimicrobial-Resistant Clinical Isolates.

Areej M Alotaibi, Nasser B Alsaleh, Alanoud T Aljasham, Essam A Tawfik, Mohammed M Almutairi, Mohammed A Assiri, Musaed Alkholief, Mashal M Almutairi

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Article
  3. Biogenesis ofInternational journal of molecular sciences · 2026
    Article
  4. Article
  5. Antibiotic resistance inFrontiers in microbiology · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. A Simple and Rapid Synthesis of Spherical Silver Phosphate (AgInternational journal of molecular sciences · 2025
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Antimicrobial activity of metal-based nanoparticles: a mini-review.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Review
  16. Article
  17. Biosynthesis and Characterization of Silver Nanoparticles Produced byInternational journal of molecular sciences · 2023
    Article
  18. Microbiology spectrum · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Areej M AlotaibiDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Nasser B AlsalehDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-2650-5934
Alanoud T AljashamDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-6564-7732
Essam A TawfikNational Center of Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi Arabia.ORCID 0000-0003-0716-3251
Mohammed M AlmutairiDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Mohammed A AssiriDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-9527-229X
Musaed AlkholiefDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia.
Mashal M AlmutairiDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-9746-4765
King Saud University · SAKing Abdulaziz City for Science and Technology · SA

Funding

The authors are thankful to the funded Researchers Supporting Project number (RSP2022R461), King Saud University, Riyadh, Saudi Arabia. RSP2022R461
6 · The paper itself

Abstract

The increasing prevalence of antimicrobial-resistant (AMR) bacteria along with the limited development of antimicrobials warrant investigating novel antimicrobial modalities. Emerging inorganic engineered nanomaterials (ENMs), most notably silver nanoparticles (AgNPs), have demonstrated superior antimicrobial properties. However, AgNPs, particularly those of small size, could exert overt toxicity to mammalian cells. This study investigated whether combining AgNPs and conventional antimicrobials would produce a synergistic response and determined the optimal and safe minimum inhibitory concentration (MIC) range against several wild-type Gram-positive and -negative strains and three different clinical isolates of AMR

Indexed as

antimicrobial agentsantimicrobial resistancecytotoxicityengineered nanomaterialsmetal nanoparticlessynergism

Identifiers

PMID36139997
PMCPMC9495250
OpenAlexW4295006280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.