Evidence map›Paper›PMID 36139953›Full record

ArticleAntibiotics (Basel, Switzerland)2022

Phage Cocktails with Daptomycin and Ampicillin Eradicates Biofilm-Embedded Multidrug-Resistant

Ashlan J Kunz Coyne, Kyle Stamper, Razieh Kebriaei, Dana J Holger, Amer El Ghali, Taylor Morrisette, Biswajit Biswas, Melanie Wilson, Michael V Deschenes, Gregory S Canfield and 3 more

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Bacteriophage-mediated reduction of Pseudomonas aeruginosa biofilm on titanium surfaces for biomedical applications.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  3. Article
  4. Impact ofAntimicrobial agents and chemotherapy · 2026
    Article
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  6. Review
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  9. Antimicrobial agents and chemotherapy · 2025
    Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Ashlan J Kunz CoyneAnti-Infective Research Laboratory, College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0002-4891-8625
Kyle StamperAnti-Infective Research Laboratory, College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
Razieh KebriaeiAnti-Infective Research Laboratory, College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0003-4019-2679
Dana J HolgerAnti-Infective Research Laboratory, College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0001-7171-7015
Amer El GhaliAnti-Infective Research Laboratory, College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
Taylor MorrisetteDepartment of Pharmacy and Clinical Services, College of Pharmacy, Medical University of South Carolina, Charleston, SC 29208, USA.
Biswajit BiswasNaval Medical Research Center, Fort Detrick, MD 21702, USA.
Melanie WilsonNaval Medical Research Center, Fort Detrick, MD 21702, USA.
Michael V DeschenesNaval Medical Research Center, Fort Detrick, MD 21702, USA.
Gregory S CanfieldDepartment of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO 80045, USA.
Breck A DuerkopDepartment of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO 80045, USA.ORCID 0000-0003-4030-9822
Cesar A AriasDivision of Infectious Diseases, Houston Methodist Hospital, Houston, TX 77030, USA.
Michael J RybakAnti-Infective Research Laboratory, College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0003-2220-0081
Wayne State University · USLeidos (United States) · USUniversity of Colorado Anschutz Medical Campus · USHouston Methodist · USMedical University of South Carolina · USNaval Medical Research Command · US

Funding

Project 3: Functional Microbiome and Host Signatures in Transition from Commensal to pathogenP01AI152999 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SAVIDGE, TOR C. · 2020 to 2025
$12.0M
VENOUS: A translational study of enterococcal bacteremiaR01AI148342 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2020 to 2024
$3.9M
The LiaFSR system and antimicrobial peptide resistance in enterococciR01AI134637 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Cesar Augusto Arias · 2018 to 2026
$3.7M
POR Program on Genomic Prediction of Antimicrobial Resistance in VREK24AI121296 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2016 to 2025
$1.5M
Enterococcus faecium virulence: A molecular and therapeutic approachR00AI072961 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2009 to 2010
$593k
Anti-biofilm activity of bacteriophage-antibiotic combinations against MRSAR21AI163726 · NIAID · WAYNE STATE UNIVERSITY · PI RYBAK, MICHAEL JOSEPH · 2021 to 2022
$424k
NIAID NIH HHS K24 AI121296NIAID NIH HHS P01 AI152999NIAID NIH HHS R01 AI134637NIAID NIH HHS R21 AI163726
6 · The paper itself

Abstract

Multidrug-resistant (MDR)

Indexed as

bacteriophage-antibiotic combinationsbacteriophage cocktailsbeta-lactamsdaptomycinEnterococcus faeciumphage-antibiotic synergy

Identifiers

PMID36139953
PMCPMC9495159
OpenAlexW4293686494

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.