Evidence map›Paper›PMID 36139926›Full record

ReviewAntibiotics (Basel, Switzerland)2022

Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials.

Mazdida Sulaiman, Khoshnur Jannat, Veeranoot Nissapatorn, Mohammed Rahmatullah, Alok K Paul, Maria de Lourdes Pereira, Mogana Rajagopal, Monica Suleiman, Mark S Butler, Mohammed Khaled Bin Break and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Efficacy of Endophytic BacteriumJournal of microbiology and biotechnology · 2025
    Article
  10. Norchelerythrine fromInternational journal of oncology · 2025
    Article
  11. Review
  12. Review
  13. Review
  14. Biofungicides Based on Plant Extracts: On the Road to Organic Farming.International journal of molecular sciences · 2024
    Review
  15. Article
  16. Article
  17. Cloning and Molecular Characterization of theAntibiotics (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 7 countries.

Mazdida SulaimanDepartment of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0002-6100-9813
Khoshnur JannatDepartment of Biotechnology & Genetic Engineering, University of Development Alternative, Dhaka 1207, Bangladesh.
Veeranoot NissapatornSchool of Allied Health Sciences and World Union for Herbal Drug Discovery (WUHeDD), Walailak University, Nakhon Si Thammarat 80160, Thailand.
Mohammed RahmatullahDepartment of Biotechnology & Genetic Engineering, University of Development Alternative, Dhaka 1207, Bangladesh.ORCID 0000-0002-0216-7977
Alok K PaulSchool of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7001, Australia.ORCID 0000-0002-6090-2407
Maria de Lourdes PereiraCICECO-Aveiro Institute of Materials & Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0001-6703-7869
Mogana RajagopalFaculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-5664-9293
Monica SuleimanInstitute for Tropical Biology & Conservation, Universiti Malaysia Sabah, Kota Kinabalu 88400, Malaysia.ORCID 0000-0002-0966-962X
Mark S ButlerMSBChem Consulting, Brisbane, QLD 4005, Australia.
Mohammed Khaled Bin BreakDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 81411, Saudi Arabia.
Jean-Frédéric WeberUFR Sciences Pharmaceutiques, INRAE, Bordeaux INP, UR ŒNOLOGIE, EA 4577, USC 1366, ISVV, Université de Bordeaux, 210 Chemin de Leysotte, 33882 Villenave d'Ornon, France.ORCID 0000-0001-9062-3591
Polrat WilairatanaDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.ORCID 0000-0002-2730-7788
Christophe WiartInstitute for Tropical Biology & Conservation, Universiti Malaysia Sabah, Kota Kinabalu 88400, Malaysia.
Universiti of Malaysia Sabah · MYUniversity of Development Alternative · BDMahidol University · THUCSI University · MYUniversité de Bordeaux · FRUniversity of Aveiro · PTUniversity of Ha'il · SAUniversity of Malaya · MYUniversity of Tasmania · AUWalailak University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of multidrug-resistant bacteria and fungi requires the development of antibiotics and antifungal agents. This review identified natural products isolated from Asian angiosperms with antibacterial and/or antifungal activities and analyzed their distribution, molecular weights, solubility, and modes of action. All data in this review were compiled from Google Scholar, PubMed, Science Direct, Web of Science, ChemSpider, PubChem, and a library search from 1979 to 2022. One hundred and forty-one antibacterial and/or antifungal alkaloids were identified during this period, mainly from basal angiosperms. The most active alkaloids are mainly planar, amphiphilic, with a molecular mass between 200 and 400 g/mol, and a polar surface area of about 50 Å

Indexed as

alkaloidsantibacterialantifungalAsiamedicinal plants

Identifiers

PMID36139926
PMCPMC9495154
OpenAlexW4293009607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.