ArticleAntioxidants (Basel, Switzerland)2022
Effects of Dietary Rutin Supplementation on the Intestinal Morphology, Antioxidant Capacity, Immunity, and Microbiota of Aged Laying Hens.
Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Dietary theabrownins alleviate age-related declines in productive performance and egg quality by improving intestinal health in laying hens.Journal of animal science and biotechnology · 2026Article
- Plant extracts to enhancing intestinal barrier function in fattening lambs: review.Animal bioscience · 2026Article
- Rutin alleviates heat stress-induced intestinal oxidative damage in broilers via AMPK/PINK1-Parkin signaling pathway.Poultry science · 2026Article
- Rutin Alleviates Oxidative Stress in Chicken Hepatocytes by Inhibiting Ribotoxic Stress Response.Animals : an open access journal from MDPI · 2026Article
- Multi-omics analysis reveals that puerarin modulates the gut-liver axis to improve hepatic health in aged laying hens.BMC genomics · 2026Article
- Effects of Leuconostoc lactis on the antioxidant ability and indole-3-acetaldehyde metabolism via regulating the gut microbiota-liver axis in aged laying hens.Animal microbiome · 2026Article
- Effects ofAnimals : an open access journal from MDPI · 2026Article
- Dietary supplementation with walnut (Frontiers in veterinary science · 2026Article
- Compound Probiotics Enhance Performance, Antioxidant Status, and Cecal SCFAs in Post-Molting Broiler Breeders.Animals : an open access journal from MDPI · 2025Article
- Water homeostasis and extracellular fluid dynamics reveal imidacloprid disruption and rutin mitigation in honey bees.Scientific reports · 2025Article
- Redox Homeostasis in Poultry/Animal Production.Antioxidants (Basel, Switzerland) · 2025Article
- Protective Effects of Magnolol, Rutin, and Gallic Acid in Broilers Challenged with Dietary Oxidized Soybean Oil.Antioxidants (Basel, Switzerland) · 2025Article
- Cocoa Polyphenols Alter the Fecal Microbiome Without Mitigating Colitis in Mice Fed Healthy or Western Basal Diets.Nutrients · 2025Article
- Physiological responses and reproductive performance of naturally heat-stressed rabbit does treated with postbiotic of Bacillus subtilis and Saccharomyces cerevisiae in free and nano-encapsulated forms.BMC veterinary research · 2025Article
- Comparative Effects of Organic and Nano-Selenium on Egg Quality and Antioxidant Capacity in Layer Hens.Foods (Basel, Switzerland) · 2025Article
- Herbal Immunostimulants and Their Phytochemicals: ExploringPlants (Basel, Switzerland) · 2025Review
- Comparative analysis of intestinal and reproductive function in older laying hens with three egg laying levels.Frontiers in microbiology · 2025Article
- Decoding electroacupuncture's efficacy: a comparative study on gut microbiota and metabolic profiles in C57 and 3xTg-AD mice.Frontiers in microbiology · 2025Article
- Economic and Productive Comparison of Rutin and Rutin-Loaded Chitosan Alginate Nanoparticles Against Lead-Induced Oxidative Stress in Cobb and Arbor Broiler Breeds.Biological trace element research · 2024Article
- Marine red yeast supplementation improves laying performance by regulating small intestinal homeostasis in aging chickens.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
This research investigated the effects of dietary rutin supplementation on the intestinal morphology, antioxidant capacity, immunity, and microbiota of aged laying hens. The results showed that 500 mg/kg rutin supplementation increased the villus height of jejunum (P < 0.05). Rutin affected the immune system of the ileum and the jejunum. In the jejunum, a diet with 500 mg/kg rutin supplementation enhanced secretory immunoglobulin A (sIgA) and reduced tumor necrosis factor-α (TNF-α) levels (P < 0.05). A diet with 1000 mg/kg rutin supplementation increased jejunal sIgA, immunologlobulin M (IgM), and interleukin-4 (IL-4) levels while decreasing interleukin-1β (IL-1β), TNF-α, and interferon-γ (IFN-γ) levels (P < 0.05). Meanwhile, a diet with 500 mg/kg rutin increased sIgA, immunologlobulin G (IgG), IgM, and interleukin-10 (IL-10) levels and reduced TNF-α and IFN-γ levels in the ileum (P < 0.05). In the ileum, a diet with 1000 mg/kg rutin supplementation raised sIgA, IgG, IgM, IL-4, and IL-10 levels while decreasing IL-1β, TNF-α, and IFN-γ levels (P < 0.05). At the family level, a diet with 500 mg/kg rutin supplementation raised the relative abundance of Monoglobaceae and decreased the relative abundance of Eubacteriaceae (P < 0.05) compared to the control group. In the 1000 mg/kg rutin group, the relative abundance of Lactobacillaceae and Unclassified Coriobacteriale was considerably lower and the relative abundance of Monoglobaceae was higher than the control group (P < 0.05). This study showed that a diet with rutin supplementation can improve the intestinal health of aged laying hens, and the mechanism is related to improving the intestinal morphology and intestinal immune status, and regulating the intestinal microbes.
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