Evidence map›Paper›PMID 36139869›Full record

ArticleAntioxidants (Basel, Switzerland)2022

DHPA Protects SH-SY5Y Cells from Oxidative Stress-Induced Apoptosis via Mitochondria Apoptosis and the Keap1/Nrf2/HO-1 Signaling Pathway.

Yunhui Cai, Ran Xiao, Yadan Zhang, Diya Xu, Ni Wang, Mengze Han, Yili Zhang, Lin Zhang, Wenhua Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
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  4. Copper homeostasis and cuproptosis in Alzheimer's disease (Review).International journal of molecular medicine · 2025
    Review
  5. Article
  6. Article
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  15. Impact of NQO1 dysregulation in CNS disorders.Journal of translational medicine · 2024
    Review
  16. Article
  17. ΔInternational journal of molecular sciences · 2023
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yunhui CaiHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, School of Food Science and Engineering, Center South University of Forestry and Technology, Changsha 410004, China.ORCID 0000-0003-2869-3921
Ran XiaoHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, School of Food Science and Engineering, Center South University of Forestry and Technology, Changsha 410004, China.
Yadan ZhangHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, School of Food Science and Engineering, Center South University of Forestry and Technology, Changsha 410004, China.
Diya XuHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, School of Food Science and Engineering, Center South University of Forestry and Technology, Changsha 410004, China.ORCID 0000-0002-3474-6711
Ni WangHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, School of Food Science and Engineering, Center South University of Forestry and Technology, Changsha 410004, China.ORCID 0000-0002-7534-1649
Mengze HanHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, School of Food Science and Engineering, Center South University of Forestry and Technology, Changsha 410004, China.ORCID 0000-0002-2702-7006
Yili ZhangHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, School of Food Science and Engineering, Center South University of Forestry and Technology, Changsha 410004, China.ORCID 0000-0002-8578-9930
Lin ZhangHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, School of Food Science and Engineering, Center South University of Forestry and Technology, Changsha 410004, China.ORCID 0000-0001-9637-205X
Wenhua ZhouHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, School of Food Science and Engineering, Center South University of Forestry and Technology, Changsha 410004, China.
Central South University of Forestry and Technology · CN

Funding

a popular science program of Hunan Province 2021ZK4227a program for Science & Technology Innovation Platform/Talents of Hunan Province 2017TP1021, 2019TP1029a program for Science and Technology of Changsha, China kq1907096a program for Science and Technology of Education Department of Hunan Province 20B620Hunan key research and development plan project 2020NK2020Natural Science Foundation of Changsha kq2202282Natural Science Foundation of Hunan Province No. 2022JJ31009, 2022JJ50260the National Natural Science Foundation of China 81501619
6 · The paper itself

Abstract

Oxidative stress in the brain is highly related to the pathogenesis of Alzheimer's disease (AD). It could be induced by the overproduction of reactive oxygen species (ROS), produced by the amyloid beta (Aβ) peptide and excess copper (Cu) in senile plaques and cellular species, such as ascorbic acid (AA) and O

Indexed as

Alzheimer’s diseasemitochondriaNrf2oxidative stressROSSH-SY5Y cell

Identifiers

PMID36139869
PMCPMC9495558
OpenAlexW4295548774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.