Evidence map›Paper›PMID 36139861›Full record

ReviewAntioxidants (Basel, Switzerland)2022

Recent Development of the Molecular and Cellular Mechanisms of Hydrogen Sulfide Gasotransmitter.

Jianyun Liu, Fikir M Mesfin, Chelsea E Hunter, Kenneth R Olson, W Christopher Shelley, John P Brokaw, Krishna Manohar, Troy A Markel

Open access · goldAbstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. The Role of Hydrogen Sulfide (HInternational journal of molecular sciences · 2023
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Hydrogen Sulfide Metabolism in the Skin: From Physiology to Malignancy.International journal of molecular sciences · 2025
    Review
  6. Review
  7. Article
  8. Review
  9. CSE/HInternational journal of molecular sciences · 2025
    Review
  10. Review
  11. Article
  12. Article
  13. Reactive Sulfur Species in Biology and Medicine.Antioxidants (Basel, Switzerland) · 2023
    Article
  14. Review
  15. Characterization of Glutathione Dithiophosphates as Long-Acting HInternational journal of molecular sciences · 2023
    Article
  16. Review
  17. Microbiota of the gastrointestinal tract: Friend or foe?World journal of gastroenterology · 2023
    Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jianyun LiuDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA.ORCID 0000-0002-6731-0375
Fikir M MesfinDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA.
Chelsea E HunterDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA.
Kenneth R OlsonDepartment of Physiology, Indiana University School of Medicine-South Bend, South Bend, IN 46617, USA.ORCID 0000-0003-0178-2203
W Christopher ShelleyDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA.
John P BrokawDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA.
Krishna ManoharDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA.ORCID 0000-0002-3576-8584
Troy A MarkelDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA.
Indiana University Health · USIndiana University South Bend · US

Funding

Neonatal gut-on-a-chip platform for high content drug testing and precision medicineR01HD105301 · NICHD · WASHINGTON UNIVERSITY · PI GOOD, MISTY L, MAGNESS, SCOTT T · 2021 to 2024
$2.4M
American College of Surgeons Clowe's Memorial Research FundGerber Foundation to TAMNational Science Foundation IOS2012106NIH HHS R01HD105301
6 · The paper itself

Abstract

Hydrogen sulfide has been recently identified as the third biological gasotransmitter, along with the more well studied nitric oxide (NO) and carbon monoxide (CO). Intensive studies on its potential as a therapeutic agent for cardiovascular, inflammatory, infectious and neuropathological diseases have been undertaken. Here we review the possible direct targets of H

Indexed as

gasotransmitterpersulfidationreactive species interactomereactive sulfur species

Identifiers

PMID36139861
PMCPMC9495975
OpenAlexW4295549142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.