Evidence map›Paper›PMID 36139855›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Lonicerae Japonicae Flos Attenuates Neutrophilic Inflammation by Inhibiting Oxidative Stress.

Kuei-Hung Lai, Yu-Li Chen, Mei-Fang Lin, Mohamed El-Shazly, Yu-Chia Chang, Po-Jen Chen, Chun-Han Su, Yen-Chun Chiu, Amina M Illias, Chih-Chuan Chen and 2 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Nonpolysaccharide fraction ofFrontiers in pharmacology · 2026
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  4. Callus Culture System fromInternational journal of molecular sciences · 2025
    Article
  5. Review
  6. Article
  7. Pharmacological Activities ofMolecules (Basel, Switzerland) · 2024
    Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 2 countries.

Kuei-Hung LaiPhD Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0001-7220-6356
Yu-Li ChenResearch Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan.ORCID 0000-0003-2392-1702
Mei-Fang LinGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Mohamed El-ShazlyDepartment of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street, Abassia, Cairo 11566, Egypt.
Yu-Chia ChangResearch Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan.ORCID 0000-0002-7849-8254
Po-Jen ChenDepartment of Medical Research, E-Da Hospital, Kaohsiung 824005, Taiwan.
Chun-Han SuDepartment of Food Science, College of Human Ecology, Fu Jen Catholic University, New Taipei City 24205, Taiwan.ORCID 0000-0002-9144-8577
Yen-Chun ChiuGraduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan.
Amina M IlliasDepartment of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.
Chih-Chuan ChenGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Lo-Yun ChenGraduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
Tsong-Long HwangResearch Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan.ORCID 0000-0002-5780-3977
Chang Gung University · TWChang Gung University of Science and Technology · TWAin Shams University · EGE-Da Hospital · TWFu Jen Catholic University · TWMing Chi University of Technology · TWTaipei Medical University · TWTaipei Medical University Hospital · TW

Funding

Chang Gung Memorial Hospital CMRPG3J0231~3Ministry of Science and Technology MOST 106-2320-B-255-003-MY3
6 · The paper itself

Abstract

Lonicerae japonicae flos (LJ) is an Asian traditional herb that is used as a dietary supplement, tea, and beverage to clear heat and quench thirst. However, no studies investigated its effect on activated human neutrophils, which played a crucial role in the bad prognosis of coronavirus disease of 2019 (COVID-19) patients by aggravating lung inflammation and respiratory failure. Herein, we evaluated the anti-inflammatory effect of LJ ethanol extract (LJEE) on human neutrophils activated by

Indexed as

bioassay-coupled chromatographic profilecalcium mobilizationhuman neutrophilsLonicerae japonicae flosSARS-CoV-2-Spike/ACE2superoxide anion (O2•−)

Identifiers

PMID36139855
PMCPMC9495740
OpenAlexW4295549508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.