Evidence map›Paper›PMID 36139811›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Polyfunctionalized α-Phenyl-tert-butyl(benzyl)nitrones: Multifunctional Antioxidants for Stroke Treatment.

Daniel Diez-Iriepa, Damijan Knez, Stanislav Gobec, Isabel Iriepa, Cristóbal de Los Ríos, Isaac Bravo, Francisco López-Muñoz, José Marco-Contelles, Dimitra Hadjipavlou-Litina

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. α-Phenyl-Antioxidants (Basel, Switzerland) · 2024
    Review
  2. Article
  3. Review
  4. Molecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Daniel Diez-IriepaLaboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
Damijan KnezFaculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0001-9917-1384
Stanislav GobecFaculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0002-9678-3083
Isabel IriepaDepartamento de Química Orgánica y Química Inorgánica, Universidad de Alcalá, Ctra. Madrid-Barcelona Km 33.6, 28871 Alcalá de Henares, Spain.ORCID 0000-0003-3475-9624
Cristóbal de Los RíosInstitute of Health Research, Hospital Universitario de la Princesa, 28006 Madrid, Spain.ORCID 0000-0002-6456-7589
Isaac BravoInstitute of Health Research, Hospital Universitario de la Princesa, 28006 Madrid, Spain.ORCID 0000-0002-7950-0838
Francisco López-MuñozFaculty of Health, Camilo José Cela University of Madrid (UCJC), Castillo Alarcon 49, 28692 Madrid, Spain.ORCID 0000-0002-5188-6038
José Marco-ContellesLaboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
Dimitra Hadjipavlou-LitinaDepartment of Pharmaceutical Chemistry, Faculty of Health Sciences, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-1844-350X
Hospital Universitario de La Princesa · ESUniversidad de Alcalá · ESUniversity of Ljubljana · SIAristotle University of Thessaloniki · GRInstituto de Salud Carlos III · ESResearch Institute Hospital 12 de Octubre · ES

Funding

Slovenian Research Agency ARRS P1-0208
6 · The paper itself

Abstract

Nowadays, most stroke patients are treated exclusively with recombinant tissue plasminogen activator, a drug with serious side effects and limited therapeutic window. For this reason, and because of the known effects of oxidative stress on stroke, a more tolerable and efficient therapy for stroke is being sought that focuses on the control and scavenging of highly toxic reactive oxygen species by appropriate small molecules, such as nitrones with antioxidant properties. In this context, herein we report here the synthesis, antioxidant, and neuroprotective properties of twelve novel polyfunctionalized α-phenyl-

Indexed as

antioxidantsbutyrylcholinesterasefree radical scavengersneuroprotectionα-phenyl-tert-butyl(benzyl)nitrones

Identifiers

PMID36139811
PMCPMC9495348
OpenAlexW4294343677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.