Evidence map›Paper›PMID 36139771›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Stress-Induced Premature Senescence Related to Oxidative Stress in the Developmental Programming of Nonalcoholic Fatty Liver Disease in a Rat Model of Intrauterine Growth Restriction.

Basile Keshavjee, Valentine Lambelet, Hanna Coppola, David Viertl, John O Prior, Laurent Kappeler, Jean-Baptiste Armengaud, Jean-Pierre Chouraqui, Hassib Chehade, Paul-Emmanuel Vanderriele and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Basile KeshavjeeDepartment of Woman-Mother-Child, Division of Pediatrics, DOHaD Laboratory, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland.
Valentine LambeletDepartment of Woman-Mother-Child, Division of Pediatrics, DOHaD Laboratory, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland.
Hanna CoppolaDepartment of Woman-Mother-Child, Division of Pediatrics, DOHaD Laboratory, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland.
David ViertlDepartment of Nuclear Medicine and Molecular Imaging, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland.
John O PriorDepartment of Nuclear Medicine and Molecular Imaging, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland.ORCID 0000-0003-1429-1374
Laurent KappelerINSERM, Centre de Recherche St Antoine, CRSA, Sorbonne Université, 75000 Paris, France.
Jean-Baptiste ArmengaudDepartment of Woman-Mother-Child, Division of Pediatrics, DOHaD Laboratory, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland.ORCID 0000-0002-2276-623X
Jean-Pierre ChouraquiDepartment of Woman-Mother-Child, Pediatric Nutrition and Gastroenterology Unit, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland.ORCID 0000-0002-6488-922X
Hassib ChehadeDepartment of Woman-Mother-Child, Division of Pediatrics, DOHaD Laboratory, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland.
Paul-Emmanuel VanderrieleDepartment of Biomedical Sciences, University of Lausanne, National Center of Competence in Research Kidney, 1011 Lausanne, Switzerland.ORCID 0000-0002-8581-8471
Manon AlloucheDepartment of Woman-Mother-Child, Division of Pediatrics, DOHaD Laboratory, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland.
Anne BalsigerDepartment of Woman-Mother-Child, Division of Pediatrics, DOHaD Laboratory, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland.
Alexandre SarreDepartment of Woman-Mother-Child, Division of Pediatrics, DOHaD Laboratory, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland.
Anne-Christine PeyterDepartment Woman-Mother-Child, Neonatal Research Laboratory, Clinic of Neonatology, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland.ORCID 0000-0003-2051-1126
Umberto SimeoniDepartment of Woman-Mother-Child, Division of Pediatrics, DOHaD Laboratory, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland.
Catherine YzydorczykDepartment of Woman-Mother-Child, Division of Pediatrics, DOHaD Laboratory, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland.ORCID 0000-0002-0617-7558
University of Lausanne · CHInserm · FR

Funding

AIRG 10172
6 · The paper itself

Abstract

Metabolic syndrome (MetS) refers to cardiometabolic risk factors, such as visceral obesity, dyslipidemia, hyperglycemia/insulin resistance, arterial hypertension and non-alcoholic fatty liver disease (NAFLD). Individuals born after intrauterine growth restriction (IUGR) are particularly at risk of developing metabolic/hepatic disorders later in life. Oxidative stress and cellular senescence have been associated with MetS and are observed in infants born following IUGR. However, whether these mechanisms could be particularly associated with the development of NAFLD in these individuals is still unknown. IUGR was induced in rats by a maternal low-protein diet during gestation versus. a control (CTRL) diet. In six-month-old offspring, we observed an increased visceral fat mass, glucose intolerance, and hepatic alterations (increased transaminase levels, triglyceride and neutral lipid deposit) in male rats with induced IUGR compared with the CTRL males; no differences were found in females. In IUGR male livers, we identified some markers of stress-induced premature senescence (SIPS) (lipofuscin deposit, increased protein expression of p21

Indexed as

cellular senescencedevelopmental programmingintrauterine growth restrictionmetabolic syndromenonalcoholic fatty liver diseaseoxidative stress

Identifiers

PMID36139771
PMCPMC9495674
OpenAlexW4293527318

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.