Evidence map›Paper›PMID 36139770›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Olanzapine Ameliorates Ischemic Stroke-like Pathology in Gerbils and H

Md Sadikul Islam, Ha-Young Shin, Yeo-Jin Yoo, Ryunhee Kim, Young-Jin Jang, Md Rashedunnabi Akanda, Hyun-Jin Tae, In-Shik Kim, Dongchoon Ahn, Byung-Yong Park

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. IMD-1 Protects SH-SY5Y Cells Against HNeurochemical research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Md Sadikul IslamInstitute of Animal Transplantation, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Korea.ORCID 0000-0002-1133-559X
Ha-Young ShinInstitute of Animal Transplantation, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Korea.
Yeo-Jin YooInstitute of Animal Transplantation, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Korea.
Ryunhee KimInstitute of Animal Transplantation, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Korea.
Young-Jin JangInstitute of Animal Transplantation, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Korea.
Md Rashedunnabi AkandaDepartment of Pharmacology and Toxicology, Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet 3100, Bangladesh.ORCID 0000-0002-5464-9353
Hyun-Jin TaeInstitute of Animal Transplantation, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Korea.ORCID 0000-0002-5193-508X
In-Shik KimInstitute of Animal Transplantation, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Korea.
Dongchoon AhnInstitute of Animal Transplantation, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Korea.
Byung-Yong ParkInstitute of Animal Transplantation, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Korea.ORCID 0000-0001-8897-2258
Jeonbuk National University · KRSylhet Agricultural University · BD

Funding

National Research Foundation of Korea NRF-2020R1F1A1076246
6 · The paper itself

Abstract

Olanzapine (OLNZ) is used to treat psychotic disorders. To look into the neurological basis of this phenomenon, we investigated the neuroprotective effects of OLNZ in gerbils and SH-SY5Y cells. Gerbils were subjected to transient global cerebral ischemia (TGCI) by blocking both common carotid arteries, and OLNZ (10 mg/kg) was injected intraperitoneally. Hydrogen peroxide (H

Indexed as

antioxidantdifferentially expressed genes (DEGs)MAPKneuroprotectionolanzapineoxidative stresstransient ischemia

Identifiers

PMID36139770
PMCPMC9495525
OpenAlexW4293527182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.