Evidence map›Paper›PMID 36139735›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Bacterial Metabolite Reuterin Attenuated LPS-Induced Oxidative Stress and Inflammation Response in HD11 Macrophages.

Yibin Xu, Xiaoqing Ding, Yuanyuan Wang, Danlei Li, Lingyu Xie, Shuang Liang, Yunfeng Zhang, Weifen Li, Aikun Fu, Xiuan Zhan

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Biosynthetic reuterin improved the intestinal health in pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026
    Article
  5. Article
  6. Effects and mechanism ofWorld journal of gastroenterology · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Frontiers in cellular and infection microbiology · 2023
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yibin XuKey Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University (Zijingang Campus), Hangzhou 310058, China.
Xiaoqing DingKey Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University (Zijingang Campus), Hangzhou 310058, China.
Yuanyuan WangKey Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University (Zijingang Campus), Hangzhou 310058, China.
Danlei LiKey Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University (Zijingang Campus), Hangzhou 310058, China.
Lingyu XieKey Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University (Zijingang Campus), Hangzhou 310058, China.
Shuang LiangKey Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University (Zijingang Campus), Hangzhou 310058, China.
Yunfeng ZhangKey Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University (Zijingang Campus), Hangzhou 310058, China.
Weifen LiKey Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University (Zijingang Campus), Hangzhou 310058, China.
Aikun FuKey Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University (Zijingang Campus), Hangzhou 310058, China.ORCID 0000-0003-4815-9769
Xiuan ZhanKey Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University (Zijingang Campus), Hangzhou 310058, China.

Funding

Key R & D program of Zhejiang Province(project: 2022C02043);China Agriculture Research System of MOF and MARA (project: CARS-41, Beijing, China);Agricultural Science and Technology Cooperation Program of Zhejiang Province (project:2021SNLF024, Hangzhou, 2022C02043;CARS-41;2021SNLF024;2021XTTGXM04
6 · The paper itself

Abstract

Reuterin is well-known for its broad-spectrum antimicrobial ability, while the other potential bioactivity is not yet clear. The present study aims to investigate the immunomodulatory activity of reuterin on chicken macrophage HD11 cells for the first time and evaluate whether reuterin is able to regulate the lipopolysaccharide-stimulated inflammatory response. The results showed that the safe medication range of reuterin was less than 250 μM. Reuterin treatment for 6 h decreased the transcriptional of

Indexed as

HD11 cell lineinflammation responselipopolysaccharide (LPS)oxidative stressreuterin

Identifiers

PMID36139735
PMCPMC9495524

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.