Evidence map›Paper›PMID 36139640›Full record

ArticleCancers2022

TRPM4 Participates in Irradiation-Induced Aortic Valve Remodeling in Mice.

Harlyne Mpweme Bangando, Christophe Simard, Margaux Aize, Alexandre Lebrun, Alain Manrique, Romain Guinamard, On Behalf Of The Stop-As Investigators

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Ion Channels in the Development and Remodeling of the Aortic Valve.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Harlyne Mpweme BangandoNormandie Université, UR 4650, Physiopathologie et Stratégies d'Imagerie du Remodelage Cardiovasculaire, GIP Cyceron, CHU de Caen, UNICAEN, Campus Jules Horowitz, BP 5229, 14074 Caen, France.
Christophe SimardNormandie Université, UR 4650, Physiopathologie et Stratégies d'Imagerie du Remodelage Cardiovasculaire, GIP Cyceron, CHU de Caen, UNICAEN, Campus Jules Horowitz, BP 5229, 14074 Caen, France.
Margaux AizeNormandie Université, UR 4650, Physiopathologie et Stratégies d'Imagerie du Remodelage Cardiovasculaire, GIP Cyceron, CHU de Caen, UNICAEN, Campus Jules Horowitz, BP 5229, 14074 Caen, France.
Alexandre LebrunNormandie Université, UR 4650, Physiopathologie et Stratégies d'Imagerie du Remodelage Cardiovasculaire, GIP Cyceron, CHU de Caen, UNICAEN, Campus Jules Horowitz, BP 5229, 14074 Caen, France.
Alain ManriqueNormandie Université, UR 4650, Physiopathologie et Stratégies d'Imagerie du Remodelage Cardiovasculaire, GIP Cyceron, CHU de Caen, UNICAEN, Campus Jules Horowitz, BP 5229, 14074 Caen, France.
Romain GuinamardNormandie Université, UR 4650, Physiopathologie et Stratégies d'Imagerie du Remodelage Cardiovasculaire, GIP Cyceron, CHU de Caen, UNICAEN, Campus Jules Horowitz, BP 5229, 14074 Caen, France.
On Behalf Of The Stop-As InvestigatorsNormandie Université, UR 4650, Physiopathologie et Stratégies d'Imagerie du Remodelage Cardiovasculaire, GIP Cyceron, CHU de Caen, UNICAEN, Campus Jules Horowitz, BP 5229, 14074 Caen, France.
Centre Hospitalier Universitaire de Caen · FRUniversité de Caen Normandie · FRNormandie Université · FRPhysiopathologie et Stratégies d'Imagerie du Remodelage cardiovasculaire

Funding

Agence Nationale de la Recherche ANR-16-RHUS-0003FHU CARNAVAL GSC G4
6 · The paper itself

Abstract

Thoracic radiotherapy can lead to cardiac remodeling including valvular stenosis due to fibrosis and calcification. The monovalent non-selective cation channel TRPM4 is known to be involved in calcium handling and to participate in fibroblast transition to myofibroblasts, a phenomenon observed during aortic valve stenosis. The goal of this study was to evaluate if TRPM4 is involved in irradiation-induced aortic valve damage. Four-month-old

Indexed as

aortic valvefibrosisstenosisTRPM4

Identifiers

PMID36139640
PMCPMC9497207
OpenAlexW4296103514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.