Evidence map›Paper›PMID 36139616›Full record

ArticleCancers2022

U-Net Based Segmentation and Characterization of Gliomas.

Shingo Kihira, Xueyan Mei, Keon Mahmoudi, Zelong Liu, Siddhant Dogra, Puneet Belani, Nadejda Tsankova, Adilia Hormigo, Zahi A Fayad, Amish Doshi and 1 more

Abstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  14. Development of A Radiomic Model forInternational journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shingo KihiraDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Xueyan MeiBiomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Keon MahmoudiDepartment of Radiological Sciences, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90033, USA.ORCID 0000-0002-2002-5710
Zelong LiuBiomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Siddhant DograDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Puneet BelaniDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Nadejda TsankovaDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Adilia HormigoDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-3259-5603
Zahi A FayadDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Amish DoshiDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kambiz NaelDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-4194-9488

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Gliomas are the most common primary brain neoplasms accounting for roughly 40−50% of all malignant primary central nervous system tumors. We aim to develop a deep learning-based framework for automated segmentation and prediction of biomarkers and prognosis in patients with gliomas. (2) Methods: In this retrospective two center study, patients were included if they (1) had a diagnosis of glioma with known surgical histopathology and (2) had preoperative MRI with FLAIR sequence. The entire tumor volume including FLAIR hyperintense infiltrative component and necrotic and cystic components was segmented. Deep learning-based U-Net framework was developed based on symmetric architecture from the 512 × 512 segmented maps from FLAIR as the ground truth mask. (3) Results: The final cohort consisted of 208 patients with mean ± standard deviation of age (years) of 56 ± 15 with M/F of 130/78. DSC of the generated mask was 0.93. Prediction for IDH-1 and MGMT status had a performance of AUC 0.88 and 0.62, respectively. Survival prediction of <18 months demonstrated AUC of 0.75. (4) Conclusions: Our deep learning-based framework can detect and segment gliomas with excellent performance for the prediction of IDH-1 biomarker status and survival.

Indexed as

deep learninggliomaisocitrate dehydrogenase 1magnetic resonance imagingradiogenomictumor segmentation

Identifiers

PMID36139616
PMCPMC9496685

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.