Evidence map›Paper›PMID 36139609›Full record

ArticleCancers2022

Radiomics for the Prediction of Overall Survival in Patients with Bladder Cancer Prior to Radical Cystectomy.

Piotr Woźnicki, Fabian Christopher Laqua, Katharina Messmer, Wolfgang Gerhard Kunz, Christian Stief, Dominik Nörenberg, Andrea Schreier, Jan Wójcik, Johannes Ruebenthaler, Michael Ingrisch and 4 more

Abstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Piotr WoźnickiDepartment of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg-Oberdürrbacher Str. 6, 97080 Würzburg, Germany.ORCID 0000-0002-9437-3785
Fabian Christopher LaquaDepartment of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg-Oberdürrbacher Str. 6, 97080 Würzburg, Germany.ORCID 0000-0002-3761-0350
Katharina MessmerDepartment of Urology, University Hospital, LMU Munich, Munich-Marchioninistr. 15, 81377 Munich, Germany.
Wolfgang Gerhard KunzDepartment of Radiology, University Hospital, LMU Munich, Munich-Marchioninistr. 15, 81377 Munich, Germany.ORCID 0000-0002-5021-1952
Christian StiefDepartment of Urology, University Hospital, LMU Munich, Munich-Marchioninistr. 15, 81377 Munich, Germany.
Dominik NörenbergDepartment of Radiology and Nuclear Medicine, University Medical Center Mannheim, Mannheim-Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
Andrea SchreierDepartment of Otolaryngology, University Hospital, LMU Munich, Munich-Marchioninistr. 15, 81377 Munich, Germany.
Jan WójcikFaculty of Medicine, Medical University of Warsaw, Żwirki i Wigury 61, 02091 Warsaw, Poland.ORCID 0000-0003-1779-0873
Johannes RuebenthalerDepartment of Radiology, University Hospital, LMU Munich, Munich-Marchioninistr. 15, 81377 Munich, Germany.ORCID 0000-0003-0832-5662
Michael IngrischDepartment of Radiology, University Hospital, LMU Munich, Munich-Marchioninistr. 15, 81377 Munich, Germany.
Jens RickeDepartment of Radiology, University Hospital, LMU Munich, Munich-Marchioninistr. 15, 81377 Munich, Germany.
Alexander BuchnerDepartment of Urology, University Hospital, LMU Munich, Munich-Marchioninistr. 15, 81377 Munich, Germany.ORCID 0000-0001-7895-7070
Gerald Bastian SchulzDepartment of Urology, University Hospital, LMU Munich, Munich-Marchioninistr. 15, 81377 Munich, Germany.ORCID 0000-0002-0340-0304
Eva GresserDepartment of Radiology, University Hospital, LMU Munich, Munich-Marchioninistr. 15, 81377 Munich, Germany.ORCID 0000-0002-2780-2025

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: To evaluate radiomics features as well as a combined model with clinical parameters for predicting overall survival in patients with bladder cancer (BCa). (2) Methods: This retrospective study included 301 BCa patients who received radical cystectomy (RC) and pelvic lymphadenectomy. Radiomics features were extracted from the regions of the primary tumor and pelvic lymph nodes as well as the peritumoral regions in preoperative CT scans. Cross-validation was performed in the training cohort, and a Cox regression model with an elastic net penalty was trained using radiomics features and clinical parameters. The models were evaluated with the time-dependent area under the ROC curve (AUC), Brier score and calibration curves. (3) Results: The median follow-up time was 56 months (95% CI: 48−74 months). In the follow-up period from 1 to 7 years after RC, radiomics models achieved comparable predictive performance to validated clinical parameters with an integrated AUC of 0.771 (95% CI: 0.657−0.869) compared to an integrated AUC of 0.761 (95% CI: 0.617−0.874) for the prediction of overall survival (p = 0.98). A combined clinical and radiomics model stratified patients into high-risk and low-risk groups with significantly different overall survival (p < 0.001). (4) Conclusions: Radiomics features based on preoperative CT scans have prognostic value in predicting overall survival before RC. Therefore, radiomics may guide early clinical decision-making.

Indexed as

bladder canceroutcome predictionradical cystectomyradiomics

Identifiers

PMID36139609
PMCPMC9497387

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.