Evidence map›Paper›PMID 36139572›Full record

ReviewCancers2022

Prostate Cancer Tumor Stroma: Responsibility in Tumor Biology, Diagnosis and Treatment.

Luis O González, Noemi Eiro, Maria Fraile, Nana Beridze, Andres R Escaf, Safwan Escaf, Jesús M Fernández-Gómez, Francisco J Vizoso

Abstract readReview
In one paragraph

Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Luis O GonzálezDepartment of Anatomical Pathology, Fundación Hospital de Jove, Avda. Eduardo Castro, 161, 33920 Gijón, Spain.
Noemi EiroResearch Unit, Fundación Hospital de Jove, Avda. Eduardo Castro, 161, 33920 Gijón, Spain.ORCID 0000-0001-5840-4807
Maria FraileResearch Unit, Fundación Hospital de Jove, Avda. Eduardo Castro, 161, 33920 Gijón, Spain.ORCID 0000-0002-0092-7805
Nana BeridzeResearch Unit, Fundación Hospital de Jove, Avda. Eduardo Castro, 161, 33920 Gijón, Spain.ORCID 0000-0002-4361-1448
Andres R EscafResearch Unit, Fundación Hospital de Jove, Avda. Eduardo Castro, 161, 33920 Gijón, Spain.
Safwan EscafDepartment of Urology, Hospital Universitario Central de Asturias, Universidad de Oviedo, Avda. de Roma s/n., 33011 Oviedo, Spain.
Jesús M Fernández-GómezDepartment of Urology, Hospital Universitario Central de Asturias, Universidad de Oviedo, Avda. de Roma s/n., 33011 Oviedo, Spain.
Francisco J VizosoResearch Unit, Fundación Hospital de Jove, Avda. Eduardo Castro, 161, 33920 Gijón, Spain.ORCID 0000-0002-2827-5511

Funding

Fundacion para la investigacion en urologia (FIU). Beca Leonardo de la Peña 2022
6 · The paper itself

Abstract

Prostate cancer (PCa) is a common cancer among males globally, and its occurrence is growing worldwide. Clinical decisions about the combination of therapies are becoming highly relevant. However, this is a heterogeneous disease, ranging widely in prognosis. Therefore, new approaches are needed based on tumor biology, from which further prognostic assessments can be established and complementary strategies can be identified. The knowledge of both the morphological structure and functional biology of the PCa stroma compartment can provide new diagnostic, prognostic or therapeutic possibilities. In the present review, we analyzed the aspects related to the tumor stromal component (both acellular and cellular) in PCa, their influence on tumor behavior and the therapeutic response and their consideration as a new therapeutic target.

Indexed as

biochemical recurrence in prostate cancercancer-associated fibroblastsexosomesextracellular vesiclesmesenchymal stromal cellstumor microenvironment

Identifiers

PMID36139572
PMCPMC9496870

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.