Evidence map›Paper›PMID 36139502›Full record

ArticleCells2022

Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson's Disease.

Dewei He, Yanting Liu, Jie Li, Hefei Wang, Bojian Ye, Yuan He, Zhe Li, Xiyu Gao, Shoupeng Fu, Dianfeng Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Dewei HeCollege of Animal Science, Jilin University, Changchun 130012, China.
Yanting LiuDepartment of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul 296-12, Korea.
Jie LiCollege of Animal Science, Jilin University, Changchun 130012, China.
Hefei WangCollege of Veterinary Medicine, Jilin University, Changchun 130012, China.
Bojian YeCollege of Veterinary Medicine, Jilin University, Changchun 130012, China.
Yuan HeCollege of Veterinary Medicine, Jilin University, Changchun 130012, China.
Zhe LiCollege of Veterinary Medicine, Jilin University, Changchun 130012, China.
Xiyu GaoCollege of Animal Science, Jilin University, Changchun 130012, China.
Shoupeng FuCollege of Veterinary Medicine, Jilin University, Changchun 130012, China.
Dianfeng LiuCollege of Animal Science, Jilin University, Changchun 130012, China.
Jilin University · CNSeoul St. Mary's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disease in which neuronal apoptosis and associated inflammation are involved in its pathogenesis. However, there is still no specific treatment that can stop PD progression. Isoalantolactone (IAL) plays a role in many inflammation-related diseases. However, its effect and mechanism in PD remain unclear. In this study, results showed that IAL administration ameliorated 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced PD-related pathological impairment and decreased motor activity in mice. Results from in vitro mechanistic studies showed that IAL regulated apoptosis-related proteins by activating the AKT/Nrf2 pathway, thereby suppressing the apoptosis of SN4741 cells induced by N-methyl-4-phenylpyridinium Iodide (MPP

Indexed as

Neurodegenerative DiseasesParkinson Disease1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine1-Methyl-4-phenylpyridiniumAnimalsApoptosisInflammationInflammation MediatorsIodidesLipopolysaccharidesMiceMice, Inbred C57BLNF-E2-Related Factor 2NF-kappa BProto-Oncogene Proteins c-aktPyrrolidines1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine1-Methyl-4-phenylpyridiniumInflammation MediatorsIodidesisoalantolactoneLipopolysaccharidesNF-E2-Related Factor 2NF-kappa BProto-Oncogene Proteins c-aktPyrrolidinesSesquiterpenesapoptosisisoalantolactoneneuro-inflammationneuro-protectionPD

Identifiers

PMID36139502
PMCPMC9497122
OpenAlexW4296460547

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.