Evidence map›Paper›PMID 36139401›Full record

ArticleCells2022

Regulatory T-Cells Suppress Cytotoxic T Lymphocyte Responses against Microglia.

Priyanka Chauhan, Shuxian Hu, Wen S Sheng, James R Lokensgard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Priyanka ChauhanNeurovirology Laboratory, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Shuxian HuNeurovirology Laboratory, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Wen S ShengNeurovirology Laboratory, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA.ORCID 0000-0002-5425-1185
James R Lokensgard3-107 Microbiology Research Facility, University of Minnesota, 689 23rd Avenue S.E., Minneapolis, MN 55455, USA.ORCID 0000-0002-1976-2035
University of Minnesota Medical Center · USUniversity of Minnesota · US

Funding

T lymphocyte-induced glial activation during CNS immune reconstitution diseaseR01MH066703 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LOKENSGARD, JAMES R · 2003 to 2023
$6.9M
NIMH NIH HHS R01 MH066703
6 · The paper itself

Abstract

Regulatory T-cells (Tregs) play pivotal roles during infection, cancer, and autoimmunity. In our previous study, we demonstrated a role for the PD-1:PD-L1 pathway in controlling cytolytic responses of CD8

Indexed as

T-Lymphocytes, CytotoxicT-Lymphocytes, RegulatoryB7-H1 AntigenCD8-Positive T-LymphocytesGranzymesImmune Checkpoint InhibitorsInterferon-gammaInterleukinsKi-67 AntigenMicrogliaProgrammed Cell Death 1 ReceptorB7-H1 AntigenGranzymesImmune Checkpoint InhibitorsInterferon-gammaInterleukinsKi-67 AntigenProgrammed Cell Death 1 Receptorcytotoxicitymicrogliaregulatory T-cells

Identifiers

PMID36139401
PMCPMC9496959
OpenAlexW4295592788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.