Evidence map›Paper›PMID 36139386›Full record

ReviewCells2022

Regulating the Expression of HIF-1α or lncRNA: Potential Directions for Cancer Therapy.

Minghui Zhang, Yu Zhang, Yubo Ding, Jialu Huang, Jingwei Yao, Zhuoyi Xie, Yufan Lv, Jianhong Zuo

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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  10. Maternal NOProceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Minghui ZhangThe Laboratory of Translational Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China.
Yu ZhangThe Laboratory of Translational Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China.
Yubo DingThe Affiliated Nanhua Hospital of University of South China, Hengyang Medical School, University of South China, Hengyang 421002, China.
Jialu HuangThe Laboratory of Translational Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China.
Jingwei YaoThe Affiliated Nanhua Hospital of University of South China, Hengyang Medical School, University of South China, Hengyang 421002, China.
Zhuoyi XieThe Laboratory of Translational Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China.
Yufan LvThe Affiliated Nanhua Hospital of University of South China, Hengyang Medical School, University of South China, Hengyang 421002, China.
Jianhong ZuoThe Laboratory of Translational Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China.
University of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have shown that tumors under a hypoxic environment can induce an important hypoxia-responsive element, hypoxia-induced factor-1α (HIF-1α), which can increase tumor migration, invasion, and metastatic ability by promoting epithelial-to-mesenchymal transition (EMT) in tumor cells. Currently, with the deeper knowledge of long noncoding RNAs (lncRNAs), more and more functions of lncRNAs have been discovered. HIF-1α can regulate hypoxia-responsive lncRNAs under hypoxic conditions, and changes in the expression level of lncRNAs can regulate the production of EMT transcription factors and signaling pathway transduction, thus promoting EMT progress. In conclusion, this review summarizes the regulation of the EMT process by HIF-1α and lncRNAs and discusses their relationship with tumorigenesis. Since HIF-1α plays an important role in tumor progression, we also summarize the current drugs that inhibit tumor progression by modulating HIF-1α.

Indexed as

NeoplasmsRNA, Long NoncodingGene Expression Regulation, NeoplasticHumansHypoxiaTranscription FactorsRNA, Long NoncodingTranscription FactorsEMTHIF-1αHIF-1α inhibitorshypoxialncRNAs

Identifiers

PMID36139386
PMCPMC9496732
OpenAlexW4294959242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.