Evidence map›Paper›PMID 36139354›Full record

ReviewCells2022

The Memory T Cell "Communication Web" in Context with Gastrointestinal Disorders-How Memory T Cells Affect Their Surroundings and How They Are Influenced by It.

Annkathrin Knauss, Michael Gabel, Markus F Neurath, Benno Weigmann

Abstract readReview
In one paragraph

Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Annkathrin KnaussMedical Clinic 1, Research Campus, University Hospital Erlangen, Hartmannstr. 14, 91052 Erlangen, Germany.
Michael GabelMedical Clinic 1, Research Campus, University Hospital Erlangen, Hartmannstr. 14, 91052 Erlangen, Germany.
Markus F NeurathMedical Clinic 1, University Hospital Erlangen, Ulmenweg 18, 91054 Erlangen, Germany.
Benno WeigmannMedical Clinic 1, Research Campus, University Hospital Erlangen, Hartmannstr. 14, 91052 Erlangen, Germany.ORCID 0000-0002-2398-0844

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut-related diseases like ulcerative colitis, Crohn's disease, or colorectal cancer affect millions of people worldwide. It is an ongoing process finding causes leading to the development and manifestation of those disorders. This is highly relevant since understanding molecular processes and signalling pathways offers new opportunities in finding novel ways to interfere with and apply new pharmaceuticals. Memory T cells (mT cells) and their pro-inflammatory properties have been proven to play an important role in gastrointestinal diseases and are therefore increasingly spotlighted. This review focuses on mT cells and their subsets in the context of disease pathogenesis and maintenance. It illustrates the network of regulatory proteins and metabolites connecting mT cells with other cell types and tissue compartments. Furthermore, the crosstalk with various microbes will be a subject of discussion. Characterizing mT cell interactions will help to further elucidate the sophisticated molecular and cellular networking system in the intestine and may present new ideas for future research approaches to control gut-related diseases.

Indexed as

Colitis, UlcerativeGastrointestinal DiseasesHumansMemory T CellsPharmaceutical PreparationsPharmaceutical Preparationscolorectal cancerCrohn’s diseaseetrolizumabIBDimmune cellsinteractionsmemory T cellsmetabolitesmicrobiotaozanimodulcerative colitisvedolizumab

Identifiers

PMID36139354
PMCPMC9497182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.