ArticleAnimals : an open access journal from MDPI2022
Effects of a Novel Gel Formulation of Dog Appeasing Pheromone (DAP) on Behavioral and Physiological Stress Responses in Dogs Undergoing Clinical Examination.
Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Enhanced environmental acclimation of cats using an innovative passive diffuser of the facial-marking pheromone (F3).Journal of feline medicine and surgery · 2026Article
- Crossing the comfort zone: rabbit appeasing pheromone enhances acclimation to a novel environment.Frontiers in veterinary science · 2026Article
- Take a Look Towards the Stress Response of Working Dogs: Cortisol and Lactate Trend Mismatches During Training.Animals : an open access journal from MDPI · 2025Article
- Helping Rabbits Cope with Veterinary Acts and Vaccine-Related Stress: The Effects of the Rabbit Appeasing Pheromone (RAP).Animals : an open access journal from MDPI · 2024Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The veterinary visit is necessary for safeguarding the health of dogs, but it can be stressful and threaten both the welfare of the patient and the accuracy of the examination. This randomized, triple-blind, placebo-controlled, crossover study aims at evaluating how dog appeasing pheromone (DAP) in a novel gel formulation influences the behavioral and physiological stress responses of 28 dogs undergoing a standardized clinical examination, while staying in the waiting room (WR) and visited in the examination room (ER). Behavioral responses were studied through behavioral categories and subjective scales (WR and ER). Autonomic response considered heart rate (WR and ER), blood pressure (WR and ER), respiratory rate (ER), and rectal temperature (ER). Neuroendocrine response considered salivary cortisol (WR and ER). In the waiting room, the use of DAP was associated with a significant reduction of lip licking (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.