Evidence map›Paper›PMID 36139236›Full record

ArticleAnimals : an open access journal from MDPI2022

Stress-Induced Immunosuppression Affects Immune Response to Newcastle Disease Virus Vaccine via Circulating miRNAs.

Yufei Tian, Yang Liu, Qiuyuan Wang, Jie Wen, Yiru Wu, Jianwei Han, Chaolai Man

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Probiotics as Potential Enhancers of Veterinary Vaccines.Probiotics and antimicrobial proteins · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yufei TianCollege of Life Science and Technology, Harbin Normal University, Harbin 150001, China.
Yang LiuCollege of Life Science and Technology, Harbin Normal University, Harbin 150001, China.
Qiuyuan WangCollege of Life Science and Technology, Harbin Normal University, Harbin 150001, China.
Jie WenCollege of Life Science and Technology, Harbin Normal University, Harbin 150001, China.
Yiru WuCollege of Life Science and Technology, Harbin Normal University, Harbin 150001, China.
Jianwei HanCollege of Life Science and Technology, Harbin Normal University, Harbin 150001, China.
Chaolai ManCollege of Life Science and Technology, Harbin Normal University, Harbin 150001, China.
Harbin Normal University · CN

Funding

Natural Science Foundation of Heilongjiang Province LH2019C073Postgraduate Innovation Project of Harbin Normal University HSDSSCX2022-32
6 · The paper itself

Abstract

Studies have shown that circulating microRNAs (miRNAs) are important players in the immune response and stress-induced immunosuppression. However, the function and mechanism of stress-induced immunosuppression affecting the immune response to the Newcastle disease virus (NDV) vaccine remain largely unknown. This study analyzed the changes of 15 NDV-related circulating miRNAs at different immune stages by qRT-PCR, aiming to explore the key timepoints, potential biomarkers, and mechanisms for the functional regulation of candidate circulating miRNAs under immunosuppressed conditions. The results showed that stress-induced immunosuppression induced differential expressions of the candidate circulating miRNAs, especially at 2 days post immunization (dpi), 14 dpi, and 28 dpi. In addition, stress-induced immunosuppression significantly affected the immune response to NDV vaccine, which was manifested by significant changes in candidate circulating miRNAs at 2 dpi, 5 dpi, and 21 dpi. The featured expressions of candidate circulating miRNAs indicated their potential application as biomarkers in immunity and immunosuppression. Bioinformatics analysis revealed that the candidate circulating miRNAs possibly regulated immune function through key targeted genes, such as Mg

Indexed as

chickencirculating miRNANewcastle diseasestress-induced immunosuppressionvaccine

Identifiers

PMID36139236
PMCPMC9495071
OpenAlexW4295548737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.