ArticleAnimals : an open access journal from MDPI2022
Physiological, Immune Response, Antioxidant Capacity and Lipid Metabolism Changes in Grazing Sheep during the Cold Season.
Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Integrated endocrine-oxidative-metabolic and trace element responses to heat and cold stress in dromedary camels (Camelus dromedarius).BMC veterinary research · 2026Article
- Impact of chronic cold stress on metabolism, colostrum quality, and lamb performance in locally adapted ewes.Tropical animal health and production · 2026Article
- Liquid chromatography-tandem mass spectrometry technology revealed differences in serum metabolites between rheumatoid arthritis patients in different seasons.Frontiers in immunology · 2026Article
- Genetic and Epigenetic Adaptation Mechanisms of Sheep Under Multi-Environmental Stress Environment.International journal of molecular sciences · 2025Review
- Integrated effects of cold acclimation: physiological mechanisms, psychological adaptations, and potential applications.Frontiers in physiology · 2025Review
- Chinese Altay sheep adapt to seasonal fluctuations in forage nutrients by changing physiological status and rumen microbial community structure.Frontiers in microbiology · 2025Article
- Sheep-derived butyrate-producingAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Effects of Long-Term Cold Stress on Growth Performance, Behavior, Physiological Parameters, and Energy Metabolism in Growing Beef Cattle.Animals : an open access journal from MDPI · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Mongolian sheep are characteristically cold-tolerant. However, their cold adaptive processes, such as the physiological feedback adjustments that occur during the cold season, remain unexplored. Therefore, the present study aimed to evaluate the physiological adaptations of Mongolian sheep in cold plateau environments. A comparative analysis of the serum biochemical parameters, immune response, antioxidant capacity, and glucose and lipid metabolism of grazing Mongolian sheep in the cold and warm seasons was conducted. The results showed that in the cold season, the glucose and lipid metabolism and thermogenesis of the grazing Mongolian sheep were notably enhanced. Moreover, the immune responses were stimulated by increased levels of cytokines, such as IL-2, IL-1β, and IL-6, during the cold season. However, the antioxidant defense system was damaged; this damage was mainly characterized by decreased activity of antioxidant enzymes and an increased level of MDA during the cold season. Overall, glucose metabolism, lipid metabolism, thermogenesis, and immune responses were stimulated to meet the requirements of organismal metabolic regulation to enable grazing Mongolian sheep to physiologically adapt to cold climatic conditions.
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