Evidence map›Paper›PMID 36139163›Full record

ArticleBiomolecules2022

Generation and Validation of an Anti-Human PANK3 Mouse Monoclonal Antibody.

Sunada Khadka, Long Vien, Paul Leonard, Laura Bover, Florian Muller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sunada KhadkaDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.ORCID 0000-0002-9844-2530
Long VienDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Paul LeonardInstitute of Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Laura BoverDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Florian MullerDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Tropism Enhanced Oncolytic Adenovirus for the Treatment of Brain TumorsP50CA127001 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Juan Fueyo · 2008 to 2026
$41.2M
Collateral Deletions Expose Targetable Metabolic Vulnerabilities in the PTEN locusR21CA226301 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MULLER, FLORIAN · 2018 to 2019
$378k
NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA127001NCI NIH HHS R21 CA226301NIH HHS 2P50CA127001-11A1NIH HHS 2P50CA127001-11A1, R21CA226301
6 · The paper itself

Abstract

Coenzyme A (CoA) is an essential co-factor at the intersection of diverse metabolic pathways. Cellular CoA biosynthesis is regulated at the first committed step-phosphorylation of pantothenic acid-catalyzed by pantothenate kinases (PANK1,2,3 in humans, PANK3 being the most highly expressed). Despite the critical importance of CoA in metabolism, the differential roles of PANK isoforms remain poorly understood. Our investigations of PANK proteins as potential precision oncology collateral lethality targets (

Indexed as

NeoplasmsPantothenic AcidAnimalsAntibodies, MonoclonalCoenzyme AHumansMicePrecision MedicineProtein IsoformsAntibodies, MonoclonalCoenzyme APantothenic AcidProtein IsoformsCoAmonoclonal antibodyPANK3pantothenate kinases

Identifiers

PMID36139163
PMCPMC9496473
OpenAlexW4296526323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.