ReviewBiomolecules2022
Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers.
Review in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 90 citations in OpenAlex.
- Electrospun Eudragit Nanofiber Mats as a Buccal Delivery Platform for Triamcinolone Acetonide.ACS omega · 2026Article
- Multiple-layer mesh from electrospinnable amyloid‑like protein and their application in treating oral ulcer.Nature communications · 2026Article
- Combined electrospun fibre-microneedle patches for enhanced transmucosal delivery of benzodiazepines and proteins.Biomaterials science · 2026Article
- Sustained-Release Microneedles for Local Delivery of Antibacterial Peptide in Acne Therapy.Polymers · 2026Article
- Fabrication and characterization of prednisolone acetate-loaded electrospun mucoadhesive nanofibers for treatment of oral lichen planus.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Cellulose and Its Derivatives-Based Skin Dressings: Design, Smart Advances and Applications.Pharmaceutics · 2026Review
- Recent Developments in Oral Drug Delivery of Prokinetic Agents: Nanoparticles and Beyond.Current drug delivery · 2026Review
- Design and Application of Multiscale Systems and Scaffolds Based on Functional Polymeric Materials in Treating Chemoradiotherapy-Induced Oral Mucositis.International journal of nanomedicine · 2026Review
- Probiotic preparations in mitigating chemotherapy-induced oral mucositis: therapeutic efficacy, mechanisms, and clinical translation potential.Frontiers in cellular and infection microbiology · 2026Review
- Advances in the treatment of recurrent aphthous stomatitis: from synthetic and natural drugs to novel drug delivery systems.Frontiers in pharmacology · 2026Review
- Innovative biomaterials in promoting intraoral wound healing: Mechanisms, applications, and challenges.Materials today. Bio · 2025Review
- Targeting the Oral Mucosa: Emerging Drug Delivery Platforms and the Therapeutic Potential of Glycosaminoglycans.Pharmaceutics · 2025Review
- A cell-free SHED lysate-hydrogel system for oral ulcer healing with anti-inflammatory and pro-angiogenic effects.Journal of nanobiotechnology · 2025Article
- Janus LAAM-loaded electrospun fibrous buccal films for treating opioid use disorder.Biomaterials · 2025Article
- Integrating synthetic polypeptides with innovative material forming techniques for advanced biomedical applications.Journal of nanobiotechnology · 2025Review
- Genetic Connectivity of Gut Microbiota and Oral Ulcers: A Mendelian Randomization Study.International dental journal · 2024Article
- Advances of antimicrobial dressings loaded with antimicrobial agents in infected wounds.Frontiers in bioengineering and biotechnology · 2024Review
- The Potential of Films as Transmucosal Drug Delivery Systems.Pharmaceutics · 2023Review
- Multifunctional polysaccharide composited microneedle for oral ulcers healing.Materials today. Bio · 2023Article
- Dual-Step Controlled Release of Berberine Hydrochloride from the Trans-Scale Hybrids of Nanofibers and Microparticles.Biomolecules · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral ulcers affect oral and systemic health and have high prevalence in the population. There are significant individual differences in the etiology and extent of the disease among patients. In the treatment of oral ulcers, nanofiber films can control the drug-release rate and enable long-term local administration. Compared to other drug-delivery methods, nanofiber films avoid the disadvantages of frequent administration and certain side effects. Electrospinning is a simple and effective method for preparing nanofiber films. Currently, electrospinning technology has made significant breakthroughs in energy-saving and large-scale production. This paper summarizes the polymers that enable oral mucosal adhesion and the active pharmaceutical ingredients used for oral ulcers. Moreover, the therapeutic effects of currently available electrospun nanofiber films on oral ulcers in animal experiments and clinical trials are investigated. In addition, solvent casting and cross-linking methods can be used in conjunction with electrospinning techniques. Based on the literature, more administration systems with different polymers and loading components can be inspired. These administration systems are expected to have synergistic effects and achieve better therapeutic effects. This not only provides new possibilities for drug-loaded nanofibers but also brings new hope for the treatment of oral ulcers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.