Evidence map›Paper›PMID 36139075›Full record

ArticleBiomolecules2022

4-OI Protects MIN6 Cells from Oxidative Stress Injury by Reducing

Jianmin Wu, Xingshi Gu, Juan Zhang, Ze Mi, Zhenhu He, Yuqian Dong, Wu Ge, Kedar Ghimire, Pengfei Rong, Wei Wang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Itaconate and its derivatives in human health and diseases.Signal transduction and targeted therapy · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Autophagy and the pancreas: Healthy and disease states.Frontiers in cell and developmental biology · 2024
    Review
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Jianmin WuInstitute for Cell Transplantation and Gene Therapy, The 3rd Xiangya Hospital of Central South University, Changsha 410000, China.ORCID 0000-0002-5031-7431
Xingshi GuInstitute for Cell Transplantation and Gene Therapy, The 3rd Xiangya Hospital of Central South University, Changsha 410000, China.
Juan ZhangInstitute for Cell Transplantation and Gene Therapy, The 3rd Xiangya Hospital of Central South University, Changsha 410000, China.
Ze MiInstitute for Cell Transplantation and Gene Therapy, The 3rd Xiangya Hospital of Central South University, Changsha 410000, China.
Zhenhu HeInstitute for Cell Transplantation and Gene Therapy, The 3rd Xiangya Hospital of Central South University, Changsha 410000, China.
Yuqian DongInstitute for Cell Transplantation and Gene Therapy, The 3rd Xiangya Hospital of Central South University, Changsha 410000, China.
Wu GeInstitute for Cell Transplantation and Gene Therapy, The 3rd Xiangya Hospital of Central South University, Changsha 410000, China.
Kedar GhimireCentre for Transplant and Renal Research (CTRR), Westmead Institute for Medical Research, The University of Sydney, Sydney 2145, NSW, Australia.ORCID 0000-0002-4672-5256
Pengfei RongInstitute for Cell Transplantation and Gene Therapy, The 3rd Xiangya Hospital of Central South University, Changsha 410000, China.
Wei WangInstitute for Cell Transplantation and Gene Therapy, The 3rd Xiangya Hospital of Central South University, Changsha 410000, China.
Xiaoqian MaInstitute for Cell Transplantation and Gene Therapy, The 3rd Xiangya Hospital of Central South University, Changsha 410000, China.
Central South University · CNThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic beta cells are highly susceptible to oxidative stress, which plays a crucial role in diabetes outcomes. Progress has been slow to identify molecules that could be utilized to enhance cell survival and function under oxidative stress. Itaconate, a byproduct of the tricarboxylic acid cycle, has both anti-inflammatory and antioxidant properties. The effects of itaconate on beta cells under oxidative stress are relatively unknown. We explored the effects of 4-octyl itaconate-a cell-permeable derivative of itaconate-on MIN6 (a beta cell model) under oxidative stress conditions caused by hypoxia, along with its mechanism of action. Treatment with 4-OI reversed hypoxia-induced cell death, reduced ROS production, and inhibited cell death pathway activation and inflammatory cytokine secretion in MIN6 cells. The 4-OI treatment also suppressed lactate dehydrogenase A (LDHA)activity, which increases under hypoxia. Treatment of cells with the ROS scavenger NAC and LDHA-specific inhibitor FX-11 reproduced the beneficial effects of 4-OI on MIN6 cell viability under oxidative stress conditions, confirming its role in regulating ROS production. Conversely, overexpression of

Indexed as

AntioxidantsOxidative StressCytokinesHumansHypoxiaLactate Dehydrogenase 5Reactive Oxygen SpeciesSuccinatesAntioxidantsCytokinesitaconic acidLactate Dehydrogenase 5Reactive Oxygen SpeciesSuccinateshypoxiaitaconatelactate dehydrogenase Aoxidative stresspancreatic beta cells

Identifiers

PMID36139075
PMCPMC9496514
OpenAlexW4294989789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.