ArticleBiomolecules2022
Changes in NMDA Receptor Function in Rapid Ischemic Tolerance: A Potential Role for Tri-Heteromeric NMDA Receptors.
Mian Xie, Tiandong Leng, Samaneh Maysami, Andrea Pearson, Roger Simon, Zhi-Gang Xiong, Robert Meller
Open access · goldAbstract read
In one paragraphArticle in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors at 2 institutions in 2 countries.
Mian XieNeuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310, USA.
Tiandong LengNeuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310, USA.
Samaneh MaysamiDepartment of Neuroscience, School of Life Sciences, Keele University, Staffordshire, Keele ST5 5BG, UK.ORCID 0000-0002-6506-3972 Andrea PearsonNeuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310, USA.
Roger SimonNeuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310, USA.
Zhi-Gang XiongNeuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310, USA.ORCID 0000-0002-2824-4168 Robert MellerNeuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310, USA.
Morehouse School of Medicine · USKeele University · GB
Funding
Training and knowledge transferU54NS060659 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI DAVIDSON, ALEC J · 2008 to 2012
$6.9MBlood transcriptomics as CT adjuvant to exclude hemorrhage in acute strokeR01NS112422 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI MELLER, ROBERT · 2020 to 2024
$2.8MThe role of cholesterol metabolic enzyme CYP46A1 and its metabolite 24S-hydroxycholesterol in ischemic stroke.R01NS128018 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI TIANDONG LENG · 2022 to 2026
$1.8MRapid ischemic tolerance: Synaptic re-organization and reduced excitotoxicityR01NS059588 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI MELLER, ROBERT · 2008 to 2012
$1.6MMechanisms of ASIC-mediated neuronal injuryR01NS104349 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI SIMON, ROGER PANCOAST · 2018 to 2023
$1.6MA Cholesterol metabolite functions as an endogenous neuroprotectant through blockade of ASICSC3GM122593 · NIGMS · MOREHOUSE SCHOOL OF MEDICINE · PI LENG, TIANDONG · 2018 to 2021
$426kNIGMS NIH HHS SC3 GM122593NINDS NIH HHS R01 NS059588NINDS NIH HHS R01 NS104349NINDS NIH HHS R01 NS112422NINDS NIH HHS R01 NS128018NINDS NIH HHS U54 NS060659
6 · The paper itselfAbstract
In this study, we characterize biophysical changes in NMDA receptor function in response to brief non-injurious ischemic stress (ischemic preconditioning). Electrophysiological studies show NMDA receptor function is reduced following preconditioning in cultured rat cortical neurons. This functional change is not due to changes in the reversal potential of the receptor, but an increase in desensitization. We performed concentration-response analysis of NMDA-evoked currents, and demonstrate that preconditioned neurons show a reduced potency of NMDA to evoke currents, an increase in Mg
Indexed as
N-MethylaspartateReceptors, N-Methyl-D-AspartateActinsAnimalsGlycineIschemiaRatsActinsGlycineN-MethylaspartateReceptors, N-Methyl-D-Aspartateischemic preconditioningischemic toleranceNMDA receptoroxygen and glucose deprivation
Identifiers
PMID36139053
PMCPMC9496625
OpenAlexW4294343839
What OpenQuestion holds
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LicenceCC BY
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