Evidence map›Paper›PMID 36139042›Full record

ReviewBiomolecules2022

The Next Frontier in Health Disparities-A Closer Look at Exploring Sex Differences in Glioma Data and Omics Analysis, from Bench to Bedside and Back.

Maria Diaz Rosario, Harpreet Kaur, Erdal Tasci, Uma Shankavaram, Mary Sproull, Ying Zhuge, Kevin Camphausen, Andra Krauze

Abstract readReview
In one paragraph

Review in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Sex-Specific Differences in Patients withAJNR. American journal of neuroradiology · 2024
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria Diaz RosarioCenter for Cancer Research, National Cancer Institute, NIH, Building 10, Bethesda, MD 20892, USA.
Harpreet KaurCenter for Cancer Research, National Cancer Institute, NIH, Building 10, Bethesda, MD 20892, USA.ORCID 0000-0003-0421-8341
Erdal TasciCenter for Cancer Research, National Cancer Institute, NIH, Building 10, Bethesda, MD 20892, USA.ORCID 0000-0001-6754-2187
Uma ShankavaramCenter for Cancer Research, National Cancer Institute, NIH, Building 10, Bethesda, MD 20892, USA.
Mary SproullCenter for Cancer Research, National Cancer Institute, NIH, Building 10, Bethesda, MD 20892, USA.
Ying ZhugeCenter for Cancer Research, National Cancer Institute, NIH, Building 10, Bethesda, MD 20892, USA.
Kevin CamphausenCenter for Cancer Research, National Cancer Institute, NIH, Building 10, Bethesda, MD 20892, USA.
Andra KrauzeCenter for Cancer Research, National Cancer Institute, NIH, Building 10, Bethesda, MD 20892, USA.ORCID 0000-0003-1634-6877

Funding

Radiation Oncology Branch - Radiation ClinicZIDBC010990 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CAMPHAUSEN, KEVIN · 2009 to 2025
$136.0M
Intramural NIH HHS ZID BC010990NCI NIH intramural program ZID BC 010990
6 · The paper itself

Abstract

Sex differences are increasingly being explored and reported in oncology, and glioma is no exception. As potentially meaningful sex differences are uncovered, existing gender-derived disparities mirror data generated in retrospective and prospective trials, real-world large-scale data sets, and bench work involving animals and cell lines. The resulting disparities at the data level are wide-ranging, potentially resulting in both adverse outcomes and failure to identify and exploit therapeutic benefits. We set out to analyze the literature on women's data disparities in glioma by exploring the origins of data in this area to understand the representation of women in study samples and omics analyses. Given the current emphasis on inclusive study design and research, we wanted to explore if sex bias continues to exist in present-day data sets and how sex differences in data may impact conclusions derived from large-scale data sets, omics, biospecimen analysis, novel interventions, and standard of care management.

Indexed as

GliomaSex CharacteristicsAnimalsFemaleHumansMaleProspective StudiesPublicationsRetrospective Studiesgenomicsgliomahealth disparitieslarge-scale dataproteomicssex differences

Identifiers

PMID36139042
PMCPMC9496358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.