Evidence map›Paper›PMID 36138936›Full record

ArticleBrain sciences2022

LRRK2 Deficiency Aggravates Sleep Deprivation-Induced Cognitive Loss by Perturbing Synaptic Pruning in Mice.

Xiaojuan Cheng, Xilin Wu, Yuying Zhang, Weian Li, Linjuan Feng, Hanlin You, Siyu Yang, Dongping Yang, Xiaochun Chen, Xiaodong Pan

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Xiaojuan ChengDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.ORCID 0000-0002-3650-1355
Xilin WuDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.ORCID 0000-0003-0893-2147
Yuying ZhangDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
Weian LiSchool of Advanced Manufacturing, Fuzhou University, Fuzhou 350108, China.
Linjuan FengDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
Hanlin YouDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
Siyu YangDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
Dongping YangResearch Institute of Artificial Intelligence, Zhejiang Laboratory, Hangzhou 310027, China.
Xiaochun ChenDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
Xiaodong PanDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.ORCID 0000-0001-9511-6986
Fujian Medical University · CNFuzhou University · CNZhejiang Lab · CN

Funding

National Natural Science Foundation of China 81901072National Natural Science Foundation of China 82071175Natural Science Foundation (Key Project) of Fujian Province 2020J02022
6 · The paper itself

Abstract

Mutations of the

Indexed as

LRRK2 deficiencymicroglial synaptic pruningREM/NREMsleep deprivation

Identifiers

PMID36138936
PMCPMC9496729
OpenAlexW4296793800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.