Evidence map›Paper›PMID 36138930›Full record

ArticleBrain sciences2022

Safety Evaluation of Employing Temporal Interference Transcranial Alternating Current Stimulation in Human Studies.

Yi Piao, Ru Ma, Yaohao Weng, Chuan Fan, Xinzhao Xia, Wei Zhang, Ginger Qinghong Zeng, Yan Wang, Zhuo Lu, Jiangtian Cui and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yi PiaoApplication Technology Center of Physical Therapy to Brain Disorders, Institute of Advanced Technology, University of Science & Technology of China, Hefei 230031, China.
Ru MaDepartment of Radiology, The First Affiliated Hospital of USTC, Hefei National Research Center for Physical Sciences at the Microscale and School of Life Science, Division of Life Science and Medicine, University of Science & Technology of China, Hefei 230027, China.
Yaohao WengDepartment of Radiology, The First Affiliated Hospital of USTC, Hefei National Research Center for Physical Sciences at the Microscale and School of Life Science, Division of Life Science and Medicine, University of Science & Technology of China, Hefei 230027, China.
Chuan FanCenters for Biomedical Engineering, School of Information Science and Technology, University of Science and Technology of China, Hefei 230027, China.
Xinzhao XiaCenters for Biomedical Engineering, School of Information Science and Technology, University of Science and Technology of China, Hefei 230027, China.
Wei ZhangDepartment of Radiology, The First Affiliated Hospital of USTC, Hefei National Research Center for Physical Sciences at the Microscale and School of Life Science, Division of Life Science and Medicine, University of Science & Technology of China, Hefei 230027, China.
Ginger Qinghong ZengApplication Technology Center of Physical Therapy to Brain Disorders, Institute of Advanced Technology, University of Science & Technology of China, Hefei 230031, China.
Yan WangDepartment of Radiology, The First Affiliated Hospital of USTC, Hefei National Research Center for Physical Sciences at the Microscale and School of Life Science, Division of Life Science and Medicine, University of Science & Technology of China, Hefei 230027, China.
Zhuo LuCenters for Biomedical Engineering, School of Information Science and Technology, University of Science and Technology of China, Hefei 230027, China.
Jiangtian CuiCenters for Biomedical Engineering, School of Information Science and Technology, University of Science and Technology of China, Hefei 230027, China.
Xiaoxiao WangCenters for Biomedical Engineering, School of Information Science and Technology, University of Science and Technology of China, Hefei 230027, China.ORCID 0000-0002-8498-7388
Li GaoSILC Business School, Shanghai University, Shanghai 201800, China.
Bensheng QiuCenters for Biomedical Engineering, School of Information Science and Technology, University of Science and Technology of China, Hefei 230027, China.
Xiaochu ZhangApplication Technology Center of Physical Therapy to Brain Disorders, Institute of Advanced Technology, University of Science & Technology of China, Hefei 230031, China.ORCID 0000-0002-7541-0130

Funding

CAS-VPST Silk Road Science Fund 2021 GLHZ202128Collaborative Innovation Program of Hefei Science Center, CAS 2020HSC-CIP001Major Project of Philosophy and Social Science Research, Ministry of Education of China 19JZD010National Natural Science Foundation of China 31771221National Natural Science Foundation of China 31800927National Natural Science Foundation of China 31900766National Natural Science Foundation of China 61773360National Natural Science Foundation of China 71874170National Natural Science Foundation of China 71942003The National Key Basic Research Program 2018YFC0831101
6 · The paper itself

Abstract

Temporal interference transcranial alternating current stimulation (TI-tACS) is a new technique of noninvasive brain stimulation. Previous studies have shown the effectiveness of TI-tACS in stimulating brain areas in a selective manner. However, its safety in modulating human brain neurons is still untested. In this study, 38 healthy adults were recruited to undergo a series of neurological and neuropsychological measurements regarding safety concerns before and after active (2 mA, 20/70 Hz, 30 min) or sham (0 mA, 0 Hz, 30 min) TI-tACS. The neurological and neuropsychological measurements included electroencephalography (EEG), serum neuron-specific enolase (NSE), the Montreal Cognitive Assessment (MoCA), the Purdue Pegboard Test (PPT), an abbreviated version of the California Computerized Assessment Package (A-CalCAP), a revised version of the Visual Analog Mood Scale (VAMS-R), a self-assessment scale (SAS), and a questionnaire about adverse effects (AEs). We found no significant difference between the measurements of the active and sham TI-tACS groups. Meanwhile, no serious or intolerable adverse effects were reported or observed in the active stimulation group of 19 participants. These results support that TI-tACS is safe and tolerable in terms of neurological and neuropsychological functions and adverse effects for use in human brain stimulation studies under typical transcranial electric stimulation (TES) conditions (2 mA, 20/70 Hz, 30 min).

Indexed as

EEGnoninvasive brain stimulationsafetytACSTITI-tACStranscranial electric stimulation

Identifiers

PMID36138930
PMCPMC9496688

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.