Evidence map›Paper›PMID 36138924›Full record

ArticleBrain sciences2022

Overexpression of GDNF in Spinal Cord Attenuates Morphine Analgesic Tolerance in Rats with Bone Cancer Pain.

Wei Xu, Zhuofeng Ding, Zongbin Song, Jian Wang, Jie Zhang, Wangyuan Zou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Wei XuDepartment of Anesthesiology, The Maternal and Child Health Hospital of Hunan Province, Changsha 410010, China.
Zhuofeng DingDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China.
Zongbin SongDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China.
Jian WangDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China.
Jie ZhangDepartment of Anesthesiology, The Maternal and Child Health Hospital of Hunan Province, Changsha 410010, China.
Wangyuan ZouDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China.ORCID 0000-0003-4813-2806
Central South University · CNHunan Provincial Maternal and Child Health Hospital · CN

Funding

Clinical Research Center for High Risk Obstetric Anesthesia & Critical Care Medicine in Hunan Province 2019SK4008National Nature Science Foundation of China 82001195National Nature Science Foundation of China 82071248Nature Science Foundation of Hunan province 2020JJ8078Nature Science Foundation of Hunan province 2022JJ30956
6 · The paper itself

Abstract

Bone cancer pain (BCP) is one of the typical and distressing symptoms in cancer patients. Morphine is a widely used analgesic drug for BCP; however, long-term morphine administration will lead to analgesic tolerance. Our previous study indicated that spinal glial cell line-derived neurotrophic factor (GDNF) exerts analgesic effects in rats with BCP. In this study, BCP was established by inoculated Walker 256 carcinoma cells into rat tibias, while morphine tolerance (MT) was induced by intrathecally injecting morphine twice daily from the 9th to 15th postoperative day (POD) in BCP rats. The BCP rats developed mechanical and thermal hyperalgesia on POD 5 and it lasted to POD 15. The analgesic effect of morphine was decreased after repeat administration. Western blots and immunochemistry tests showed that GDNF was gradually decreased in the spinal cord after the development of MT in rats with BCP, and GDNF was colocalized with the μ opioid receptor (MOR) in the superficial laminate of the spinal cords. The overexpression of GDNF by lentivirus significantly attenuated MT, and restored the expression of MOR in the spinal cord. In summary, our results suggest that the reduction of GDNF expression participated in the development of MT in rats with BCP and could be a promising therapeutic option for BCP.

Indexed as

bone cancer painglial cell line-derived neurotrophic factorMORmorphine tolerancespinal

Identifiers

PMID36138924
PMCPMC9496664
OpenAlexW4294989700

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.