Evidence map›Paper›PMID 36138923›Full record

ArticleBrain sciences2022

Global and Regional Structural Differences and Prediction of Autistic Traits during Adolescence.

Frauke Nees, Tobias Banaschewski, Arun L W Bokde, Sylvane Desrivières, Antoine Grigis, Hugh Garavan, Penny Gowland, Yvonne Grimmer, Andreas Heinz, Rüdiger Brühl and 19 more

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Linking Brain Morphometry to Psychometric Measures and Energy-Metabolic Biomarkers in Adults With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 15 institutions in 7 countries.

Frauke NeesInstitute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, 24118 Kiel, Germany.ORCID 0000-0002-7796-8234
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.ORCID 0000-0003-4595-1144
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.
Sylvane DesrivièresInstitute of Psychiatry, Psychology & Neuroscience, Centre for Population Neuroscience and Precision Medicine (PONS), SGDP Centre, King's College London, London WC2R 2LS, UK.
Antoine GrigisNeuroSpin, CEA, Université Paris-Saclay, 91191 Gif-sur-Yvette, France.
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05405, USA.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2QL, UK.ORCID 0000-0002-4900-4817
Yvonne GrimmerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.
Andreas HeinzDepartment of Psychiatry and Psychotherapy CCM and Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 10117 Berlin, Germany.ORCID 0000-0001-5405-9065
Rüdiger BrühlPhysikalisch-Technische Bundesanstalt (PTB), 38116 Braunschweig, Germany.
Corinna IsenseeDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, 37075 Göttingen, Germany.
Andreas BeckerDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, 37075 Göttingen, Germany.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires Développementales en Psychiatrie", Université Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS, Centre Borelli, 91190 Gif-sur-Yvette, France.
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires Développementales en Psychiatrie", Université Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS, Centre Borelli, 91190 Gif-sur-Yvette, France.
Eric ArtigesInstitut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires Développementales en Psychiatrie", Université Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS, Centre Borelli, 91190 Gif-sur-Yvette, France.ORCID 0000-0003-4461-7646
Dimitri Papadopoulos OrfanosDepartments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05405, USA.
Hervé LemaîtreInstitut des Maladies Neurodégénératives, UMR 5293, CNRS, CEA, Université de Bordeaux, 33076 Bordeaux, France.
Argyris StringarisNational Institute of Mental Health/NIH, 15K North Drive, Bethesda, MD 20892, USA.
Betteke van NoortMSB Medical School Berlin, Hochschule für Gesundheit und Medizin, Siemens Villa, 14197 Berlin, Germany.
Tomáš PausDepartments of Psychology, University of Toronto, Toronto, ON M5T 2S8, Canada.
Jani PenttiläCanadaDepartment of Social and Health Care, Psychosocial Services Adolescent Outpatient Clinic Kauppakatu 14, 15140 Lahti, Finland.
Sabina MillenetDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.
Juliane H FröhnerDepartment of Psychiatry, Neuroimaging Center, Technische Universität Dresden, 01069 Dresden, Germany.
Michael N SmolkaSchool of Psychology, Global Brain Health Institute, Trinity College Dublin, Dublin 2, Ireland.ORCID 0000-0001-5398-5569
Henrik WalterDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, 37075 Göttingen, Germany.
Robert WhelanSchool of Psychology, Global Brain Health Institute, Trinity College Dublin, Dublin 2, Ireland.ORCID 0000-0002-2790-7281
Gunter SchumannDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.
Luise PoustkaInstitut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires Développementales en Psychiatrie", Université Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS, Centre Borelli, 91190 Gif-sur-Yvette, France.
On Behalf Of The Imagen Consortium
École Normale Supérieure Paris-Saclay · FRHeidelberg University · DETrinity College Dublin · IEUniversity of Göttingen · DEUniversity of Vermont · USCentre National de la Recherche Scientifique · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRHumboldt-Universität zu Berlin · DEKing's College London · GBNational Institute of Mental Health · USPhysikalisch-Technische Bundesanstalt · DESiemens (Germany) · DETechnische Universität Dresden · DEUniversity of Nottingham · GBUniversity of Toronto · CA

Funding

Medical Research Council MR/N000390/1Medical Research Council MR/R00465X/1Medical Research Council MR/S020306/1Medical Research Council MR/W002418/1MRF_ MRF-058-0004-RG-DESRIMRF_ MRF-058-0009-RG-DESR-C0759
6 · The paper itself

Abstract

backgroundAutistic traits are commonly viewed as dimensional in nature, and as continuously distributed in the general population. In this respect, the identification of predictive values of markers such as subtle autism-related alterations in brain morphology for parameter values of autistic traits could increase our understanding of this dimensional occasion. However, currently, very little is known about how these traits correspond to alterations in brain morphology in typically developing individuals, particularly during a time period where changes due to brain development processes do not provide a bias. Therefore, in the present study, we analyzed brain volume, cortical thickness (CT) and surface area (SA) in a cohort of 14-15-year-old adolescents (N = 285, female: N = 162) and tested their predictive value for autistic traits, assessed with the social responsiveness scale (SRS) two years later at the age of 16-17 years, using a regression-based approach. We found that autistic traits were significantly predicted by volumetric changes in the amygdala (

Indexed as

adolescentsautism spectrum disorderautistic traitssocial responsivenessstructural imaging

Identifiers

PMID36138923
PMCPMC9496772
OpenAlexW4294989913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.