ArticleBrain sciences2022
Acute Vagus Nerve Stimulation Facilitates Short Term Memory and Cognitive Flexibility in Rats.
Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 22 citations in OpenAlex.
- Effect of transcutaneous cervical vagus nerve stimulation on declarative and working memory in patients with Posttraumatic Stress Disorder (PTSD): A pilot study.Journal of affective disorders · 2023Trial
- Vagal nerve stimulation induces vascular oscillations and enhances long-term learning.iScience · 2026Article
- A Multiscale Spatiotemporal Causal Mapping Algorithm for Revealing Neural Network Mechanisms of Transcutaneous Auricular Vagus Nerve Stimulation.Human brain mapping · 2026Article
- Non-invasive Vagal Nerve Stimulation as a Potential Treatment for Repetitive Blast Trauma.bioRxiv : the preprint server for biology · 2026Article
- Vagus Nerve Stimulation Attenuates Cognitive Impairment in Traumatic Brain Injury via the mtDNA/cGAS-STING/NLRP3 Inflammasome Axis.Neurocritical care · 2026Article
- Vagus nerve stimulation: a potential tool to further improve perioperative anesthesia management quality and postoperative recovery?Frontiers in medicine · 2026Review
- Pairing extinction training with vagus nerve stimulation reduces drug-seeking by altering activity in afferents to the medial prefrontal cortex.Frontiers in neuroscience · 2026Article
- Pairing extinction training with vagus nerve stimulation (VNS) reduces drug-seeking by altering activity in afferents to the medial prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Vagal Sensory Gut-Brain Pathways That Control Eating-Satiety and Beyond.Comprehensive physiology · 2025Review
- Transcutaneous Auricular Vagus Nerve Stimulation Restores Cognitive Impairment in Morphine-Withdrawn Rats: Role of BDNF and Glial Cells in the Hippocampus.Addiction biology · 2025Article
- Associations between peripheral nerve stimulation and cognitive performance: insights from healthy individuals and various disease pathologies.Frontiers in aging neuroscience · 2025Review
- Vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans: A pilot study.PloS one · 2025Article
- Impact of transcutaneous auricular vagus nerve stimulation (taVNS) on cognitive flexibility as a function of task complexity.Frontiers in human neuroscience · 2025Article
- tDCS-induced enhancement of cognitive flexibility in autism: role of frontal lobe and associated neural circuits.Frontiers in behavioral neuroscience · 2025Article
- Optogenetic inhibition of the locus coeruleus blocks vagus nerve stimulation-induced enhancement of extinction of conditioned fear in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Vagus nerve stimulation during training fails to improve learning in healthy rats.Scientific reports · 2024Article
- Article
- The gut-brain axis and cognitive control: A role for the vagus nerve.Seminars in cell & developmental biology · 2024Review
- Transcutaneous auricular vagus nerve stimulation as a potential therapy for attention deficit hyperactivity disorder: modulation of the noradrenergic pathway in the prefrontal lobe.Frontiers in neuroscience · 2024Review
- Therapeutically targeting the consequences of HIV-1-associated gastrointestinal dysbiosis: Implications for neurocognitive and affective alterations.Pharmacology, biochemistry, and behavior · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Vagus nerve stimulation (VNS) causes the release of several neuromodulators, leading to cortical activation and deactivation. The resulting preparatory cortical plasticity can be used to increase learning and memory in both rats and humans. The effects of VNS on cognition have mostly been studied either in animal models of different pathologies, and/or after extended VNS. Considerably less is known about the effects of acute VNS. Here, we examined the effects of acute VNS on short-term memory and cognitive flexibility in naïve rats, using three cognitive tasks that require comparatively brief (single session) training periods. In all tasks, VNS was delivered immediately before or during the testing phase. We used a rule-shifting task to test cognitive flexibility, a novel object recognition task to measure short-term object memory, and a delayed spontaneous alternation task to measure spatial short-term memory. We also analyzed exploratory behavior in an elevated plus maze to determine the effects of acute VNS on anxiety. Our results indicate that acute VNS can improve memory and cognitive flexibility relative to Sham-stimulation, and these effects are independent of unspecific VNS-induced changes in locomotion or anxiety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.