ReviewBiology2022
The Sheep as a Large Animal Model for the Investigation and Treatment of Human Disorders.
Review in Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed.
- Cross-species characterisation of microglial morphology and proliferation during ageing.GeroScience · 2026Article
- Morphometric Brain Changes in a Merino Sheep (Biology · 2026Article
- From farm to lab: gene-edited sheep transforming bone research.JBMR plus · 2026Review
- Development and preliminary validation of a hybrid three-dimension printed model for glaucoma drainage device surgery training: a prospective simulation-based study.BMC ophthalmology · 2026Article
- Periprosthetic Joint Infection: Biofilm Pathogenesis, Immune Dysregulation, and Emerging Prosthetic Interface Strategies.Biology · 2026Review
- Comparative Morphometric and Structural Analysis of the Ovine Brain: Integrating Traditional Anatomical Methods with Artificial Intelligence-Driven 3D Modeling and Identification.Veterinary sciences · 2026Article
- Impact of mechanical unloading on the irisin precursor, FNDC5, in skeletal muscle of sheep as a large animal experimental model.JBMR plus · 2026Article
- Mapping the Scientific Literature on Sheep and Goat Research: General Appraisal and Significance of the Year of Publication.Animals : an open access journal from MDPI · 2026Article
- Comparative Single-Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Ovine Brain as a Model for Human Neurodevelopment: Immunohistochemical Profiling of Brain Maturation Markers in Preterm Lambs.The Journal of comparative neurology · 2026Article
- A 50-year perspective on the use and potential of artiodactyl calcanei in bone adaptation studies.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Osteomyelitis related lameness across animal species: pathophysiology, etiology, epidemiology and experimental model approaches.Frontiers in veterinary science · 2026Review
- Large animal models for the assessment of snakebite envenoming therapies.npj drug discovery · 2026Review
- Exploring epigenetic modifications following maternal immune activation: a focus on cross-species translational potential.Frontiers in cellular neuroscience · 2026Review
- Ovarian antral follicle dynamics from birth through reproductive maturity: a mini-review.Frontiers in endocrinology · 2026Review
- Ovine models of intervertebral disc degeneration.Annals of translational medicine · 2025Review
- Assessing Executive Cognitive Functions in Sheep: A Scoping Review of Recent Literature on Cognitive Tasks.Animals : an open access journal from MDPI · 2025Review
- Proteomic and morphologic characterization of ovine macrophage differentiation and polarization.Scientific reports · 2025Article
- In Vitro Antibacterial Efficacy of a New TiONanomaterials (Basel, Switzerland) · 2025Article
- Developmental programming: Differing impact of prenatal testosterone and prenatal bisphenol-A -treatment on hepatic methylome in female sheep.Molecular and cellular endocrinology · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
An essential aim of biomedical research is to translate basic science information obtained from preclinical research using small and large animal models into clinical practice for the benefit of humans. Research on rodent models has enhanced our understanding of complex pathophysiology, thus providing potential translational pathways. However, the success of translating drugs from pre-clinical to clinical therapy has been poor, partly due to the choice of experimental model. The sheep model, in particular, is being increasingly applied to the field of biomedical research and is arguably one of the most influential models of human organ systems. It has provided essential tools and insights into cardiovascular disorder, orthopaedic examination, reproduction, gene therapy, and new insights into neurodegenerative research. Unlike the widely adopted rodent model, the use of the sheep model has an advantage over improving neuroscientific translation, in particular due to its large body size, gyrencephalic brain, long lifespan, more extended gestation period, and similarities in neuroanatomical structures to humans. This review aims to summarise the current status of sheep to model various human diseases and enable researchers to make informed decisions when considering sheep as a human biomedical model.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.