Evidence map›Paper›PMID 36138681›Full record

ReviewChildren (Basel, Switzerland)2022

A Review of the Multi-Systemic Complications of a Ketogenic Diet in Children and Infants with Epilepsy.

Kyra Newmaster, Zahra Zhu, Elizabeth Bolt, Ryan J Chang, Christopher Day, Asmaa Mhanna, Sita Paudel, Osman Farooq, Arun Swaminathan, Prakrati Acharya and 7 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Children (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 2 countries.

Kyra NewmasterCollege of Medicine, Penn State University, Hershey, PA 17033, USA.ORCID 0000-0002-5544-1220
Zahra ZhuCollege of Medicine, Penn State University, Hershey, PA 17033, USA.
Elizabeth BoltCollege of Medicine, Penn State University, Hershey, PA 17033, USA.
Ryan J ChangCollege of Medicine, Penn State University, Hershey, PA 17033, USA.ORCID 0000-0002-9710-8047
Christopher DayCollege of Medicine, Penn State University, Hershey, PA 17033, USA.
Asmaa MhannaCollege of Medicine, University of Toledo, Toledo, OH 43614, USA.
Sita PaudelDepartment of Pediatrics and Neurology, Penn State Health Milton Hershey Medical Center, Hershey, PA 17033, USA.
Osman FarooqDepartment of Neurology, University at Buffalo, Buffalo, NY 14202, USA.
Arun SwaminathanDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Prakrati AcharyaDivision of Nephrology, Texas Tech Health Sciences Center El Paso, El Paso, TX 79905, USA.
Wisit CheungpasitpornDepartment of Medicine, Mayo Clinic, Division of Nephrology and Hypertension, Rochester, MN 55905, USA.ORCID 0000-0001-9954-9711
Siddharth GuptaKennedy Krieger Institute, Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA.
Debopam SamantaChild Neurology Section, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA.ORCID 0000-0002-5154-8717
Naeem MahfoozCollege of Medicine, University of Toledo, Toledo, OH 43614, USA.
Gayatra MainaliDepartment of Pediatrics and Neurology, Penn State Health Milton Hershey Medical Center, Hershey, PA 17033, USA.
Paul R CarneyPediatric Neurology Division, University of Missouri Health Care-Columbia, Columbia, MO 65201, USA.
Sunil NaikDepartment of Pediatrics and Neurology, Penn State Health Milton Hershey Medical Center, Hershey, PA 17033, USA.ORCID 0000-0002-0482-4547
Penn State Milton S. Hershey Medical Center · USAl-Quds University · PSKennedy Krieger Institute · USMayo Clinic · USTexas Tech University · USUniversity at Buffalo, State University of New York · USUniversity of Arkansas for Medical Sciences · USUniversity of Missouri Health System · USUniversity of Nebraska Medical Center · USUniversity of Toledo · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ketogenic diets (KDs) are highly effective in the treatment of epilepsy. However, numerous complications have been reported. During the initiation phase of the diet, common side effects include vomiting, hypoglycemia, metabolic acidosis and refusal of the diet. While on the diet, the side effects involve the following systems: gastrointestinal, hepatic, cardiovascular, renal, dermatological, hematologic and bone. Many of the common side effects can be tackled easily with careful monitoring including blood counts, liver enzymes, renal function tests, urinalysis, vitamin levels, mineral levels, lipid profiles, and serum carnitine levels. Some rare and serious side effects reported in the literature include pancreatitis, protein-losing enteropathy, prolonged QT interval, cardiomyopathy and changes in the basal ganglia. These serious complications may need more advanced work-up and immediate cessation of the diet. With appropriate monitoring and close follow-up to minimize adverse effects, KDs can be effective for patients with intractable epilepsy.

Indexed as

childrenepilepsyketogenic dietmodified atkins dietnutritionpediatricsseizures

Identifiers

PMID36138681
PMCPMC9498174
OpenAlexW4295592087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.