ArticleChildren (Basel, Switzerland)2022
Neurobehavioral Associations with NREM and REM Sleep Architecture in Children with Autism Spectrum Disorder.
Article in Children (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Article
- Sleep Problems and Clinical Severity in Rett Syndrome.Journal of child neurology · 2026Article
- Sleep problems in autistic children and adolescents: an age-stratified approach.Frontiers in psychology · 2026Article
- Sleep Disturbances and Behavioral Problems in Children and Adolescents with Autism Spectrum Disorder-A Systematic Review.Clinics and practice · 2025Review
- Effects of Extremely Low-Frequency Electromagnetic Field Treatment on ASD Symptoms in Children: A Pilot Study.Brain sciences · 2024Article
- Sleep architecture is associated with core symptom severity in autism spectrum disorder.Sleep · 2023Article
- M1M2: Deep-Learning-Based Real-Time Emotion Recognition from Neural Activity.Sensors (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveInsomnia and daytime behavioral problems are common issues in pediatric autism spectrum disorder (ASD), yet specific underlying relationships with NonRapid Eye Movement sleep (NREM) and Rapid Eye Movement (REM) sleep architecture are understudied. We hypothesize that REM sleep alterations (REM%, REM EEG power) are associated with more internalizing behaviors and NREM sleep deficits (N3%; slow wave activity (SWA) 0.5-3 Hz EEG power) are associated with increased externalizing behaviors in children with ASD vs. typical developing controls (TD).
methodsIn an age- and gender-matched pediatric cohort of
resultsControlling for non-verbal IQ and medication use, ASD and TD children have similar REM and NREM sleep architecture. Only ASD children show positive relationships between REM%, REM theta power and REM beta power with internalizing scores. Only TD participants showed an inverse relationship between NREM SWA and externalizing scores.
conclusionREM sleep measures reflect concerning internalizing behaviours in ASD and could serve as a biomarker for mood disorders in this population. While improving deep sleep may help externalizing behaviours in TD, we do not find evidence of this relationship in ASD.
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Registered trials
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