Evidence map›Paper›PMID 36138442›Full record

ArticleBMC research notes2022

The squiggle tail (squig) mutation in mice is associated with a deletion in the mesenchyme homeobox 1 (Meox1) gene.

Jon P Girard, Jacqueline F Tomasiello, Juan I Samuel-Constanzo, Nia Montero, Angelina M Kendra, Thomas R King

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jon P GirardDepartment of Biomolecular Sciences, Central CT State University, 1615 Stanley Street, New Britain, CT, 06053, USA.
Jacqueline F TomasielloDepartment of Biomolecular Sciences, Central CT State University, 1615 Stanley Street, New Britain, CT, 06053, USA.
Juan I Samuel-ConstanzoDepartment of Biomolecular Sciences, Central CT State University, 1615 Stanley Street, New Britain, CT, 06053, USA.
Nia MonteroDepartment of Biomolecular Sciences, Central CT State University, 1615 Stanley Street, New Britain, CT, 06053, USA.
Angelina M KendraDepartment of Biomolecular Sciences, Central CT State University, 1615 Stanley Street, New Britain, CT, 06053, USA.
Thomas R KingDepartment of Biomolecular Sciences, Central CT State University, 1615 Stanley Street, New Britain, CT, 06053, USA. kingt@ccsu.edu.ORCID http://orcid.org/0000-0001-6332-5484
Central Connecticut State University · US

Funding

Central Connecticut State University AFKINRCentral Connecticut State University AFKIZRConnecticut State Colleges and University System ARKINP
6 · The paper itself

Abstract

objectiveWe have taken a positional approach to assign the spontaneous squiggle tail (squig) mutation in mice to a specific gene defect.

resultsA large panel of backcross mice was produced and characterized to map squig to high genetic resolution on mouse Chromosome (Chr) 11. Two overlapping candidate genes that co-localized with squig (Meox1, for mesenchyme homeobox 1; and Gm11551, which encodes a lncRNA located entirely within the first intron of Meox1) were fully sequenced to discover any squig-specific defects. This analysis revealed a 3195 bp deletion that includes all of Meox1, Exon 1 but does not disrupt Gm11551. We recommend that the squig mutation be renamed Meox1

Indexed as

Homeodomain ProteinsRNA, Long NoncodingTranscription FactorsAnimalsGenes, HomeoboxMesodermMiceMutationTailHomeodomain ProteinsMeox1 protein, mouseRNA, Long NoncodingTranscription FactorsDeletion mutationKlippel-Feil syndrome 2Positional cloningTail variant

Identifiers

PMID36138442
PMCPMC9502874
OpenAlexW4296793948

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.