ArticleMicrobiome2022
Longitudinal disease-associated gut microbiome differences in infants with food protein-induced allergic proctocolitis.
Article in Microbiome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Microbiota Signatures in Early Life and Their Association With Food Allergy: A Systematic Review.Allergy · 2026Pooled it
- GUT MICROBIOTA IN INFANTS WITH COW MILK ALLERGY: A SYSTEMATIC REVIEW OF CONTROLLED STUDIES.Arquivos de gastroenterologia · 2026Pooled it
- Longitudinal Follow-Up of Gut and Salivary Microbiota in Children With Food Protein-Induced Enterocolitis Syndrome.Allergy · 2026Article
- Strain-level microbial signatures and inferred functional alterations in infants with food protein-induced allergic proctocolitis.Genome medicine · 2026Article
- Interactions between host genetics and gut microbiome influence susceptibility to childhood asthma and lung function.The Journal of allergy and clinical immunology · 2026Article
- Early-life microbiome trajectories as biomarkers to predict health outcomes.Microbiome research reports · 2026Review
- Gut microbiota alters the Th1/Th2 balance and aggravates food-allergic enteropathy in a mouse model.Bioscience of microbiota, food and health · 2026Article
- Fecal calprotectin and other biomarkers are not prospectively associated with food protein-induced allergic proctocolitis.Journal of pediatric gastroenterology and nutrition · 2026Observational
- Diagnosis and Management of Food Protein-Induced Allergic Proctocolitis.Current gastroenterology reports · 2025Review
- Predicting allergy and postpartum depression from an incomplete compositional microbiome.BMC genomics · 2025Article
- High Rate of Positive Fecal Occult Blood Test in Healthy Infants: A Nested Case-control Study.Journal of translational gastroenterology · 2025Article
- Allergic proctocolitis: Evaluation and management.Journal of food allergy · 2025Review
- Mycobiome of low maintenance iconic landscape plant boxwood under repeated treatments of contact and systemic fungicides.Scientific reports · 2025Article
- Gut Microbiota Differences in Infants with Cow-Milk-Induced Allergic Proctocolitis: A Comparative Cross-Sectional Study.Children (Basel, Switzerland) · 2025Article
- Bioinformatics Identification and Experimental Validation of a Prognostic Model for the Survival of Lung Squamous Cell Carcinoma Patients.Biochemical genetics · 2025Article
- The Immunological Mechanisms Involved in the Pathophysiology of Allergic Proctocolitis.Children (Basel, Switzerland) · 2025Article
- Enhanced Bioactivity of FermentedCurrent issues in molecular biology · 2025Article
- Influence of gut microbiota on the pediatric endocrine system and associated disorders.Annals of medicine and surgery (2012) · 2025Review
- Advances in research on gut microbiota and allergic diseases in children.Current research in microbial sciences · 2025Review
- Gut mycobiome maturation and its determinants during early childhood: a comparison of ITS2 amplicon and shotgun metagenomic sequencing approaches.Frontiers in microbiology · 2025Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundComplex interactions between the gut microbiome and immune cells in infancy are thought to be part of the pathogenesis for the marked rise in pediatric allergic diseases, particularly food allergies. Food protein-induced allergic proctocolitis (FPIAP) is commonly the earliest recognized non-immunoglobulin E (IgE)-mediated food allergy in infancy and is associated with atopic dermatitis and subsequent IgE-mediated food allergy later in childhood. Yet, a large prospective longitudinal study of the microbiome of infants with FPIAP, including samples prior to symptom onset, has not been done.
resultsHere, we analyzed 954 longitudinal samples from 160 infants in a nested case-control study (81 who developed FPIAP and 79 matched controls) from 1 week to 1 year of age by 16S rRNA ribosomal gene sequencing as part of the Gastrointestinal Microbiome and Allergic Proctocolitis (GMAP) study. We found key differences in the microbiome of infants with FPIAP, most strongly a higher abundance of a genus of Enterobacteriaceae and a lower abundance of a family of Clostridiales during the symptomatic period. We saw some of these significant taxonomic differences even prior to symptom onset. There were no consistent longitudinal differences in richness or stability diversity metrics between infants with FPIAP and healthy controls.
conclusionsThis study is the first to identify differences in the infant gut microbiome in children who develop FPIAP, some even before they develop symptoms, and provides a foundation for more mechanistic investigation into the pathogenesis of FPIAP and subsequent food allergic diseases in childhood. Video abstract.
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