Evidence map›Paper›PMID 36138430›Full record

ReviewJournal of translational medicine2022

Host-microbiome interactions regarding peri-implantitis and dental implant loss.

Carlos Henrique Alves, Karolayne Larissa Russi, Natália Conceição Rocha, Fábio Bastos, Michelle Darrieux, Thais Manzano Parisotto, Raquel Girardello

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 3 pooled it
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 98 citations in OpenAlex.

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  9. Bacteriophage-mediated reduction of Pseudomonas aeruginosa biofilm on titanium surfaces for biomedical applications.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Carlos Henrique Alves *Laboratório de Microbiologia Molecular E Clínica, Programa de Pós-Graduação Em Ciências da Saúde, Universidade São Francisco, 218, São Francisco Ave., Bragança Paulista, São Paulo, Zip code: # 12916900, Brazil.
Karolayne Larissa Russi *Laboratório de Microbiologia Molecular E Clínica, Programa de Pós-Graduação Em Ciências da Saúde, Universidade São Francisco, 218, São Francisco Ave., Bragança Paulista, São Paulo, Zip code: # 12916900, Brazil.
Natália Conceição RochaLaboratório de Microbiologia Molecular E Clínica, Programa de Pós-Graduação Em Ciências da Saúde, Universidade São Francisco, 218, São Francisco Ave., Bragança Paulista, São Paulo, Zip code: # 12916900, Brazil.
Fábio BastosUniversidade Cruzeiro Do Sul, São Paulo, Brazil.
Michelle DarrieuxLaboratório de Microbiologia Molecular E Clínica, Programa de Pós-Graduação Em Ciências da Saúde, Universidade São Francisco, 218, São Francisco Ave., Bragança Paulista, São Paulo, Zip code: # 12916900, Brazil.
Thais Manzano ParisottoLaboratório de Microbiologia Molecular E Clínica, Programa de Pós-Graduação Em Ciências da Saúde, Universidade São Francisco, 218, São Francisco Ave., Bragança Paulista, São Paulo, Zip code: # 12916900, Brazil.
Raquel GirardelloLaboratório de Microbiologia Molecular E Clínica, Programa de Pós-Graduação Em Ciências da Saúde, Universidade São Francisco, 218, São Francisco Ave., Bragança Paulista, São Paulo, Zip code: # 12916900, Brazil. raquel.girardello@usf.edu.br.ORCID 0000-0002-7117-0651
Universidade São Francisco · BRUniversidade Cruzeiro do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last decades, the ortho-aesthetic-functional rehabilitation had significant advances with the advent of implantology. Despite the success in implantology surgeries, there is a percentage of failures mainly due to in loco infections, through bacterial proliferation, presence of fungi and biofilm formation, originating peri-implantitis. In this sense, several studies have been conducted since then, seeking answers to numerous questions that remain unknown. Thus, the present work aims to discuss the interaction between host-oral microbiome and the development of peri-implantitis. Peri-implantitis was associated with a diversity of bacterial species, being Porphiromonas gingivalis, Treponema denticola and Tannerella forsythia described in higher proportion of peri-implantitis samples. In a parallel role, the injury of peri-implant tissue causes an inflammatory response mediated by activation of innate immune cells such as macrophages, dendritic cells, mast cells, and neutrophils. In summary, the host immune system activation may lead to imbalance of oral microbiota, and, in turn, the oral microbiota dysbiosis is reported leading to cytokines, chemokines, prostaglandins, and proteolytic enzymes production. These biological processes may be responsible for implant loss.

Indexed as

Dental ImplantsMicrobiotaPeri-ImplantitisCytokinesHumansPeptide HydrolasesPorphyromonas gingivalisProstaglandinsCytokinesDental ImplantsPeptide HydrolasesProstaglandinsBiofilmDental implantsOral diseasesOral microbiomePeri-implantitis

Identifiers

PMID36138430
PMCPMC9502891
OpenAlexW4296794860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.