ArticleBMC cancer2022
Association between the TyG index and TG/HDL-C ratio as insulin resistance markers and the risk of colorectal cancer.
Article in BMC cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 5 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 5 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- The Associations Between the TyG Index and the Risk of Cancer-A Systematic Review and Meta-Analysis.Cancer medicine · 2025Pooled it
- Association between the triglyceride-glucose index (TyG Index) and risk of colorectal cancer: a systematic review and meta-analysis.World journal of surgical oncology · 2025Pooled it
- Relationships of triglyceride-glucose-related indices with colorectal cancer incidence and mortality in an American population: a dose-response meta-analysis and cohort study.Lipids in health and disease · 2025Pooled it
- The association of triglyceride-glucose index with cancer incidence and mortality: a systematic review and meta-analysis of cohort studies.Frontiers in endocrinology · 2025Pooled it
- Association between triglyceride-glucose index and risk of colorectal carcinogenesis: a meta-analysis of observational studies.Frontiers in oncology · 2025Pooled it
- Trial
- eGDR and gastrointestinal cancer mortality in the UK Biobank: a prospective cohort study.BMC cancer · 2026Article
- Article
- The Triglyceride-Glucose Index and Colorectal Adenoma: A CHungcheong Association for the Study of Intestinal Disease (CHASID) Multi-Center Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Association Between Triglyceride-Glucose Index and Risk of Cancer: A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2026Review
- Development and validation of a preoperative glycolipid metabolism-based nomogram for predicting postoperative recurrence in primary glioma: a retrospective cohort study.Lipids in health and disease · 2026Article
- Triglyceride-to-glucose index and lymphocyte-to-monocyte ratio enhance prognostic accuracy for colorectal cancer patients: a multicenter machine learning cohort study.Translational cancer research · 2026Article
- Development and internal validation of a prognostic model for hepatocellular carcinoma after liver resection based on the albumin-bilirubin score and triglyceride-glucose index.Translational cancer research · 2026Article
- Nomogram incorporating TyG index and TG/HDL ratio for early prediction of gestational diabetes mellitus.BMC pregnancy and childbirth · 2026Article
- Association between four indirect indicators of insulin resistance and lung cancer: evidence from UK biobank and Mendelian randomization analysis.BMC cancer · 2026Article
- High-fat diet, triglyceride glucose index, and gastrointestinal cancer: integrative insights from human and animal studies.Frontiers in nutrition · 2026Article
- TyG index is associated with colorectal adenomatous polyps and genetically linked to colon polyps: a cross-sectional and Mendelian randomization study.Frontiers in oncology · 2026Article
- Association of four non-insulin-based insulin resistance surrogate markers with colorectal cancer risk: a large-scale prospective cohort study using the UK Biobank.Frontiers in endocrinology · 2026Article
- "Paradoxical" prognostic role of the TyG index and a novel machine learning-derived nomogram for colorectal cancer liver metastases.Frontiers in nutrition · 2026Article
- Prognostic Significance of the Triglyceride-to-High-Density Lipoprotein Cholesterol Ratio (TG/HDL-C) in Breast Cancer Patients: A Real-World Retrospective Study.Breast cancer (Dove Medical Press) · 2026Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNo previous prospective research has explored the association of the TyG (fasting triglyceride-glucose) index and TG/HDL-C ratio as insulin resistance markers with the risk of colorectal cancer (CRC) incidence in the Northern Chinese population.
methodsIn this prospective cohort study, we included 93,659 cancer-free participants with the measurements of TyG index and TG/HDL-C ratio. Participants were divided by the quartiles of the TyG index or TG/HDL-C ratio. The associations of TyG index, TG/HDL-C ratio, and their components with CRC risk were assessed using Cox proportional hazards regression models.
resultsDuring a median follow-up of 13.02 years, 593 incident CRC cases were identified. Compared with the lowest quartile of the TyG index (Q1), the risk of CRC was higher in persons in the third (Q3) and highest quartiles (Q4) of the TyG index, with corresponding multivariable-adjusted HRs (95% CI) of 1.36 (1.06, 1.76) and 1.50 (1.19, 1.91), respectively. The elevated risks of CRC incidence were observed in people in the second, third, and highest quartiles of the TG/HDL-C ratio groups, with corresponding multivariable-adjusted HRs (95% CI) of 1.33 (1.05, 1.70), 1.36 (1.07, 1.73) and 1.37 (1.07, 1.75), respectively.
conclusionsElevated TyG index and TG/HDL-C ratio were associated with a higher risk of developing CRC among adults in Northern China.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.