SynthesisBreast cancer research and treatment2022
The role of pre-operative axillary ultrasound in assessment of axillary tumor burden in breast cancer patients: a systematic review and meta-analysis.
Synthesis in Breast cancer research and treatment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07791771 (Prospective Evaluation of Sentinel Lymph Node Biopsy Combined With Wire Localized Lymph Node Biopsy for Omitting Axillary Lymph Node Dissection in Breast Cancer Patients With 1-2 Sonographically Abnormal Lymph Nodes), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Evaluation of Sentinel Lymph Node Biopsy Combined With Wire Localized Lymph Node Biopsy for Omitting Axillary Lymph Node Dissection in Breast Cancer Patients With 1-2 Sonographically Abnormal Lymph Nodes: A Diagnostic Study
Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Ultrasound-Guided Axillary Management in Early-Stage Breast Cancer: From Diagnosis to De-Escalation.Cancers · 2026Review
- AlEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Dual role of intraoperative ultrasound in axillary surgery: enhanced detection and surgical de-escalation in breast cancer.World journal of surgical oncology · 2026Article
- Impact of axillary management approaches on postoperative complication rates in breast cancer and exploration of targeted prevention strategies.American journal of cancer research · 2026Article
- Selected Pathological Criteria That Predict Low Rates of Axillary Lymph Node Metastases Regardless of Patient Age: A Single Institution Study.The breast journal · 2026Article
- Multiphase dynamic contrast-enhanced magnetic resonance imaging radiomics nomogram for predicting axillary lymph node metastasis in breast cancer.Gland surgery · 2025Article
- De-escalating axillary surgery in node-positive early breast cancer patients undergoing primary surgery: current evidence and recommendations.Journal of the Egyptian National Cancer Institute · 2025Review
- BJS commission on the surgical management of the axilla in breast cancer.The British journal of surgery · 2025Article
- Applying a multi-task and multi-instance framework to predict axillary lymph node metastases in breast cancer.NPJ precision oncology · 2025Article
- Article
- Are Clinically Node-Negative Patients with a Positive Preoperative Axillary Lymph Node Biopsy Appropriate Candidates for Sentinel Lymph Node Biopsy?Annals of surgical oncology · 2025Article
- Predicting the axillary lymph node tumor burden in breast cancer patients using ultrasonic radiomics nomogram model.PloS one · 2025Article
- Optimal management of breast cancer with physical exam negative/radiological abnormal axilla.Scientific reports · 2024Article
- Reliability of predicting low-burden (≤ 2) positive axillary lymph nodes indicating sentinel lymph node biopsy in primary operable breast cancer - a retrospective comparative study with PET/CT and breast MRI.World journal of surgical oncology · 2024Article
- The value of microvascular Doppler ultrasound technique, qualitative or quantitative shear-wave elastography of breast lesions for predicting axillary nodal burden in patients with breast cancer.Quantitative imaging in medicine and surgery · 2024Article
- Early Warning of Axillary Lymph Node Metastasis in Breast Cancer Patients Using Multi-Omics Signature: A Machine Learning-Based Retrospective Study.International journal of general medicine · 2024Article
- Axillary ultrasound for predicting response to neoadjuvant treatment in breast cancer patients-a single institution experience.World journal of surgical oncology · 2023Article
- Axillary surgery in the case of limited involved axillary lymph nodes.Gland surgery · 2023Article
- Development and validation of an ultrasonography and clinicopathological features-based nomogram for non-sentinel lymph node metastasis.Gland surgery · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have suggested that a significant proportion of patients with axillary nodal metastases diagnosed by pre-operative axillary ultrasound (AUS)-guided needle biopsy were over-treated with axillary lymph node dissection (ALND). The role of routine AUS and needle biopsy in early breast cancer was questioned. This review aims to determine if pre-operative AUS could predict the extent of axillary tumor burden and need of ALND.
methodsPubMed and Embase literature databases were searched systematically for abnormal AUS characteristics and axillary nodal burden. Studies were eligible if they correlated the sonographic abnormalities in AUS with the resultant axillary nodal burden in ALND according to the ACOSOG Z0011 criteria.
resultsEleven retrospective studies and one prospective study with 1658 patients were included. Sixty-five percent of patients with one abnormal lymph node in AUS and 56% of those with two had low axillary nodal burden. Using one abnormal lymph node as the cut-off, the pooled sensitivity and specificity in prediction of axillary nodal burden were 66% (95%CI 63-69%) and 73% (95% CI 70-76%), respectively. Across the six studies that evaluated suspicious nodal characteristics, increased nodal cortical thickness may be associated with high axillary nodal burden.
conclusionMore than half of the patients with pre-operative positive AUS and biopsy proven axillary nodal metastases were over-treated by ALND. Quantification of suspicious nodes and extent of cortical morphological changes in AUS may help identify suitable patients for sentinel lymph node biopsy.
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