Evidence map›Paper›PMID 36138246›Full record

SynthesisSurgical endoscopy2022

Minimally invasive versus open hepatectomy for the resection of colorectal liver metastases: a systematic review and meta-analysis.

Ahmad Ozair, Amelia Collings, Alexandra M Adams, Rebecca Dirks, Bradley S Kushner, Iswanto Sucandy, David Morrell, Ahmed M Abou-Setta, Timothy Vreeland, Jake Whiteside and 15 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Surgical endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 20 institutions in 4 countries.

Ahmad Ozair *Faculty of Medicine, King George's Medical University, Uttar Pradesh, Lucknow, India.
Amelia Collings *Department of Surgery, Indiana University, Indianapolis, IN, USA.
Alexandra M AdamsDepartment of Surgery, Brooke Army Medical Centre, Fort Sam Houston, San Antonio, TX, USA.
Rebecca DirksDepartment of Surgery, Indiana University, Indianapolis, IN, USA.
Bradley S KushnerDepartment of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Iswanto SucandyDigestive Health Institute, AdventHealth Tampa, Tampa, FL, USA.
David MorrellDepartment of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.
Ahmed M Abou-SettaDepartment of Community Health Sciences, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Timothy VreelandDepartment of Surgery, Brooke Army Medical Centre, Fort Sam Houston, San Antonio, TX, USA.
Jake WhitesideDepartment of Surgery, Indiana University, Indianapolis, IN, USA.
Jordan M CloydDivision of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Mohammed T AnsariSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Sean P ClearyDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA.
Eugene CeppaDepartment of Surgery, Indiana University, Indianapolis, IN, USA.
William RichardsonSection of General Surgery, Oschner Clinic, New Orleans, LA, USA.
Adnan AlseidiDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Ziad AwadDepartment of Surgery, University of Florida College of Medicine-Jacksonville, Jacksonville, FL, USA.
Subhashini AylooDepartment of Surgery, Warren Alpert Medical School, Brown University, Providence, RI, USA.
Joseph F BuellDivision of Surgery, Mission Healthcare System, HCA Healthcare, Asheville, NC, USA.
Georgios OrthopoulosDepartment of Surgery, University of Massachusetts Chan Medical School-Baystate, Springfield, MA, USA.
Samer SbayiDepartment of Surgery, Renaissance School of Medicine, Stony Brook University, New York, NY, USA.
Go WakabayashiCenter for Advanced Treatment of Hepatobiliary and Pancreatic Diseases, Department of Surgery, Ageo Central General Hospital, Ageo City, Japan.
Bethany J SlaterDepartment of Surgery, University of Chicago Medicine, Chicago, IL, USA.
Aurora PryorDepartment of Surgery, Stony Brook University, Stony Brook, NY, USA.
D Rohan JeyarajahDepartment of Surgery, TCU School of Medicine, and Methodist Richardson Medical Center, 2805 East President George Bush Highway, Fort Worth, TX, USA. rohanjeyarajah@gmail.com.ORCID http://orcid.org/0000-0002-1673-678X
Indiana University – Purdue University Indianapolis · USJoint Base San Antonio · USAdventHealth Tampa · USBrown University · USHakodate Central General Hospital · JPKing George's Medical University · INMayo Clinic in Arizona · USMethodist Richardson Medical Center · USMission Health · USPenn State Milton S. Hershey Medical Center · USStony Brook School · USStony Brook University · USThe Ohio State University Wexner Medical Center · USUniversity of California, San Francisco · USUniversity of Chicago · USUniversity of Florida · USUniversity of Manitoba · CAUniversity of Massachusetts Chan Medical School · USUniversity of Ottawa · CAWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile surgical resection has a demonstrated utility for patients with colorectal liver metastases (CRLM), it is unclear whether minimally invasive surgery (MIS) or an open approach should be used. This review sought to assess the efficacy and safety of MIS versus open hepatectomy for isolated, resectable CRLM when performed separately from (Key Question (KQ) 1) or simultaneously with (KQ2) the resection of the primary tumor.

methodsPubMed, Embase, Google Scholar, Cochrane CENTRAL, International Clinical Trials Registry Platform (ICTRP), and ClinicalTrials.gov databases were searched to identify both randomized controlled trials (RCTs) and non-randomized comparative studies published during January 2000-September 2020. Two independent reviewers screened literature for eligibility, extracted data from included studies, and assessed internal validity using the Cochrane Risk of Bias 2.0 Tool and the Newcastle-Ottawa Scale. A random-effects meta-analysis was performed using risk ratios (RR) and mean differences (MD).

resultsFrom 2304 publications, 35 studies were included for meta-analysis. For staged resections, three RCTs and 20 observational studies were included. Data from RCTs indicated MIS having similar disease-free survival (DFS) at 1-year (RR 1.03, 95%CI 0.70-1.50), overall survival (OS) at 5-years (RR 1.04, 95%CI 0.84-1.28), fewer complications of Clavien-Dindo Grade III (RR 0.62, 95%CI 0.38-1.00), and shorter hospital length of stay (LOS) (MD -6.6 days, 95%CI -10.2, -3.0). For simultaneous resections, 12 observational studies were included. There was no evidence of a difference between MIS and the open group for DFS-1-year, OS-5-year, complications, R0 resections, blood transfusions, along with lower blood loss (MD -177.35 mL, 95%CI -273.17, -81.53) and shorter LOS (MD -3.0 days, 95%CI -3.82, -2.17).

conclusionsCurrent evidence regarding the optimal approach for CRLM resection demonstrates similar oncologic outcomes between MIS and open techniques, however MIS hepatectomy had a shorter LOS, lower blood loss and complication rate, for both staged and simultaneous resections.

Indexed as

Colorectal NeoplasmsLaparoscopyLiver NeoplasmsHepatectomyHumansLength of StayMinimally Invasive Surgical ProceduresColorectal cancerLaparoscopic hepatectomyLaparoscopic surgeryLiver tumorMetastasectomyMinimally invasive surgery

Identifiers

PMID36138246
OpenAlexW4296685279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.