Evidence map›Paper›PMID 36138138›Full record

ArticleJournal of exposure science & environmental epidemiology2023

The association between household biomass fuel use and leukocyte telomere length among toddlers in Bhaktapur, Nepal.

Ram K Chandyo, Catherine Schwinger, Ingrid Kvestad, Manjeswori Ulak, Suman Ranjitkar, Merina Shrestha, Linda Vy Nguyen, Diana Corona-Perez, Immaculata DeVivo, Laxman Shrestha and 1 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of exposure science & environmental epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02272842 (The Effect of Vitamin B12 Supplementation in Nepali Infants on Growth and Development), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 66% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02272842 phase2 / phase3unknown statusnot on this map

The Effect of Vitamin B12 Supplementation in Nepali Infants on Growth and Development

TypeinterventionalSponsorCentre For International HealthRan2015 to 2024Enrolled600ConditionsDevelopment, Vitamin Deficiency, MalnutritionArmsVitamin B12
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Ram K ChandyoDepartment of Community Medicine, Kathmandu Medical College, Kathmandu, Nepal.ORCID http://orcid.org/0000-0003-2352-4424
Catherine SchwingerCentre for Intervention Science in Maternal and Child Health, Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Ingrid KvestadRegional Centre for Child and Youth Mental Health and Child Welfare, NORCE Norwegian Research Centre, Bergen, Norway.
Manjeswori UlakCentre for Intervention Science in Maternal and Child Health, Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Suman RanjitkarDepartment of Child Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.
Merina ShresthaDepartment of Child Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.
Linda Vy NguyenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Diana Corona-PerezDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Immaculata DeVivoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Laxman ShresthaDepartment of Child Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.
Tor A StrandCentre for Intervention Science in Maternal and Child Health, Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. tor.strand@uib.no.
Tribhuvan University · NPBrigham and Women's Hospital · USInnlandet Hospital Trust · NOKathmandu Medical College Teaching Hospital · NPUniversity of Bergen · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBiomass fuels are still in use for cooking by many households in resource poor countries such as Nepal and is a major source of household air pollution (HAP). Chronic exposure to HAP has been shown to be associated with shorter telomere length in adults.

objectivesTo measure the association between exposure related to household biomass fuel in infancy and leukocyte telomere length (LTL) at 18-23 months of age among 497 children from Bhaktapur, Nepal.

methodsIn a prospective cohort study design, we have collected information on household cooking fuel use and several clinical, anthropometric, demographic, and socioeconomic variables. We estimated the association between biomass fuel use and the relative LTL in multiple linear regression models.

resultsMost of the families (78%) reported liquified petroleum gas (LPG) as the primary cooking fuel, and 18.7% used biomass. The mean relative (SD) LTL was 1.03 (0.19). Children living in households using biomass fuel had on average 0.09 (95% CI: 0.05 to 0.13) units shorter LTL than children in households with no biomass fuel use. The observed association was unaltered after adjusting for relevant confounders. The association between LTL and biomass use was strongest among children from households with ≤2 rooms and without separate kitchen. SIGNIFICANCE: Exposure to biomass fuel use in early life might have consequences for longevity, and risk of chronic illnesses reflected in shortening of the telomeres. Our findings support the ongoing effort to reduce exposure to biomass fuel in low-resource settings. IMPACT STATEMENTS: Biomass for cooking is a leading source of household air pollution in low and middle-income countries, contributing to many chronic diseases and premature deaths. Chronic exposure to biomass fuel through oxidative stress and inflammation has been associated with a shortening of the telomeres, a "biological marker" of longevity. This prospective cohort study describes the association between household biomass fuel use and leukocyte telomere length among 497 toddlers. Leukocyte telomere length was significantly shorter among children living in households with biomass fuel than in children from homes where mainly LPG was used for cooking. CLINICAL

trial registrationClinicaltrials.gov: NCT02272842, registered October 21, 2014, Universal Trial Number: U1111-1161-5187 (September 8, 2014).

Indexed as

Air Pollution, IndoorPetroleumAdultChild, PreschoolCookingHumansLeukocytesNepalProspective StudiesTelomerePetroleumBiomass fuelChildrenLeukocyte telomere lengthNepal

Identifiers

PMID36138138
PMCPMC10234806
OpenAlexW4296655576

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.